| 鲍亮,赵晨,刘琮,朱鹏,周涛,张兵.膝关节液和血清肿瘤坏死因子与IL-1的临床意义.[J].中南医学科学杂志.,2020,(5):458-460, 464. |
| 膝关节液和血清肿瘤坏死因子与IL-1的临床意义 |
| Implication of tumor necrosis factor and interleukin-1 in knee joint fluid and serum |
| 投稿时间：2020-03-05 修订日期：2020-08-26 |
| DOI：10.15972/j.cnki.43-1509/r.2020.05.003 |
| 中文关键词: 骨性关节炎 膝关节 白细胞介素-1 肿瘤坏死因子 |
| 英文关键词:osteoarthritis knee joint interleukin-1 tumor necrosis factor-α |
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| 中文摘要: |
| 探讨膝关节骨性关节炎(KOA)患者膝关节液和血清白介素-1(IL-1)与肿瘤坏死因子(TNF-α)水平高低与病变程度的关系,选取从本院收治的130例KOA患者作为KOA组,其中KOA早期56例,中期42例,晚期32例；另选同期接受健康体检者50例作为对照组。ELISA检测并比较两组膝关节液和血清中IL-1与TNF-α的水平。结果显示,KOA患者膝关节液和血清中的IL-1与TNF-α水平明显高于正常对照组,随着病变程度的加重,膝关节液和血清中的IL-1与TNF-α水平显著增高。结果说明,骨性关节炎患者膝关节液和血清中IL-1与TNF-α均升高,且与病变程度呈正相关,联合检测这两项指标对早期诊断膝骨性关节炎有一定的指导意义。 |
| 英文摘要: |
| To investigate the relationships between the levels of sy1novial fluid and serum interleukin-1 (IL-1) and tumor necrosis factor TNF-α (TNF-α) in patients with osteoarthritis of knee (KOA), 130 patients with KOA from our hospital were selected as KOA group, including 56 cases of early KOA, 42 cases of middle stage, 32 cases of terminal stage, and 50 cases of healthy volunteers as control group. The levels of IL-1 and TNF-α in sy2novial fluid and serum were detected by ELISA. Results showed, the levels of IL-1 and TNF-α of KOA patients were significantly higher than that of the control group,and which were significantly increased with the severity of the disease. In conclusion, the increasing IL-1 and TNF-α in the synovial liquid and serum of KOA patients have a positive correlation with the degree of disease. The combined detection of these two indexes could be useful for early diagnosis of the knee osteoarthritis. |
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