| 梁珂莹,刘君,曾焱华,何军.发酵支原体MALP-2生物学作用研究进展.[J].中南医学科学杂志.,2020,(5):449-453. |
| 发酵支原体MALP-2生物学作用研究进展 |
| The progress of immunologic mechanisms of mycoplasma fermentans macrophage-activating lipopeptide-2 |
| 投稿时间：2020-05-07 修订日期：2020-08-13 |
| DOI：10.15972/j.cnki.43-1509/r.2020.05.001 |
| 中文关键词: 发酵支原体 巨噬细胞活化脂肽-2 生物学作用 致病机制 |
| 英文关键词:mycoplasma fermentans macrophage-activating lipopeptide-2 immuno- logic mechanisms pathogenesis |
| 基金项目: |
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| 中文摘要: |
| 巨噬细胞活化脂肽-2(MALP-2)是发酵支原体(Mf)上极具代表性的外膜脂肽,N端为特殊的二酰化半胱氨酸残基结构。MALP-2是一把“双刃剑”,在致炎与抗炎、细胞凋亡与抗凋亡、免疫佐剂、生物协同与抑制、血管损伤和血管修复等方面发挥重要作用。因此,了解MALP-2复杂的生物学作用能为理解Mf的致病机制及其临床治疗方案提供依据,同时也为MALP-2的临床应用提供理论基础。 |
| 英文摘要: |
| Macrophage-activating lipopeptide-2(MALP-2) is a classical mycoplasma-derived outer membrane lipopeptide on Mycoplasma fermentans (Mf) with a special diacylated cysteine residue structure at the N-terminal. MALP-2 poses as a double-edged sword that plays an important role in inflammation and anti-inflammation, apoptosis and anti-apoptosis, immune adjuvant, biological synergy, biological inhibition, vascular injury and vascular repair, etc. Therefore, making out the complex immunologic mechanisms of MALP-2 can provide a basis for understanding the pathogenesis of Mf and its clinical treatment, which also provides a theoretical basis for the clinical application of MALP-2. |
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