| 严秋江,范秀晶,杨妍,杨水源,梁金成,曾泗宇.吴茱萸次碱通过调控表皮生长因子受体活化抑制高血压心肌肥大.[J].中南医学科学杂志.,2020,(4):349-355. |
| 吴茱萸次碱通过调控表皮生长因子受体活化抑制高血压心肌肥大 |
| Rutaecarpine against hypertensive cardiac hypertrophy via inhibiting epidermal growth factor receptor activation |
| 投稿时间：2020-05-28 修订日期：2020-06-07 |
| DOI：10.15972/j.cnki.43-1509/r.2020.04.004 |
| 中文关键词: 吴茱萸次碱 高血压心肌肥大 表皮生长因子受体 炎症反应 细胞外调节蛋白激酶1/2 |
| 英文关键词:rutaecarpine hypertensive cardiac hypertrophy epidermal growth factor receptor cardiac inflammation extracellular signal regulated kinase |
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| 中文摘要: |
| 探讨抑制表皮生长因子受体(EGFR)活化是否调控中药单体药吴茱萸次碱的抗高血压心肌肥大效应及其机理。以腹主动脉缩窄(AAC)介导的高血压大鼠为研究对象,观察吴茱萸次碱对高血压心肌肥大、心肌炎症反应以及左心室中EGFR和细胞外调节蛋白激酶1/2(ERK1/2)活性的影响。结果显示,吴茱萸次碱能显著抑制AAC介导的高血压心肌肥大、心肌炎症反应以及EGFR、ERK1/2活化。并且,选择性EGFR抑制剂AG1478能改善AAC介导的高血压心肌肥大和心肌炎症反应,抑制ERK1/2活化。结果提示,吴茱萸次碱通过抑制EGFR活化改善AAC介导的高血压大鼠心肌肥大,其机制与其抑制ERK1/2活化和心肌炎症反应有关。 |
| 英文摘要: |
| To explore whether inhibiting epidermal growth factor receptor (EGFR) regulates the beneficial role of rutaecarpine in hypertensive cardiac hypertrophy. Abdominal artery constriction (AAC)-induced hypertensive rats were adopted to explore the effects of rutaecarpine on hypertensive cardiac hypertrophy, cardiac inflammation, and the activity of EGFR and extracellular signal regulated kinase (ERK1/2). Results indicated that rutaecarpine significantly attenuated hypertensive cardiac hypertrophy and cardiac inflammation, as well as the activity of EGFR and ERK1/2 in the left ventricle of AAC-induced hypertensive rats. Moreover, treating with selective EGFR inhibitor AG1478 alleviated hypertensive cardiac hypertrophy and cardiac inflammation, and it caused a marked reduction in ERK1/2 activity in the left ventricle of AAC-induced hypertensive rats. In summary, rutaecarpine improves hypertensive cardiac hypertrophy through inhibition of EGFR activation via inhibiting ERK1/2 activity and cardiac inflammation. |
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