| 钟丽丽,郭文俊,汪洪.丁丙诺啡透皮贴在髋关节置换术患者中的镇痛效果及对OPG/RANKL、炎症因子水平的影响分析.[J].中南医学科学杂志.,2020,(2):164-167. |
| 丁丙诺啡透皮贴在髋关节置换术患者中的镇痛效果及对OPG/RANKL、炎症因子水平的影响分析 |
| Anesthesia effect of buprenorphine transdermal patch in elderly patients undergoing hip replacement and its influence on OPG/RANKL and inflammatory factors |
| 投稿时间：2019-07-19 修订日期：2019-10-27 |
| DOI：10.15972/j.cnki.43-1509/r.2020.02.013 |
| 中文关键词: 丁丙诺啡透皮贴 髋关节置换术 镇痛 核因子κB受体活化因子配体/骨保护素 |
| 英文关键词:buprenorphine transdermal patch hip replacement anesthesia nuclear factor kappa B receptor activating factor ligand/osteoprotegerin |
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| 中文摘要: |
| 分析丁丙诺啡透皮贴在髋关节置换术患者中的镇痛效果及对骨保护素/受体活化因子(OPG/RANKL)、炎症因子水平的影响。80例髋关节置换术患者按药物不同分为对照组(n=40)和观察组(n=40)。对照组患者给予氯诺昔康(8 mg/次,每日2次),观察组患者给予丁丙诺啡透皮贴(5 mg)。治疗结果表明两组患者在术后4 h、16 h及1天的VAS评分方面差异无统计学意义,而术后2天和术后7天观察组患者的视觉模拟评分(VAS评分)明显低于对照组患者(P<0.05)；两组患者术后OPG均明显升高而RANKL和炎症因子C反应蛋白(CRP)、同型半胱氨酸(Hcy)、白细胞介素1β(IL1β)及白细胞介素2(IL2)水平均明显降低(P<0.05),且观察组患者的上述指标变化比对照组患者更显著(P<0.05)。因此,丁丙诺啡透皮贴对髋关节置换术患者中的镇痛效果长效,且能明显降低血清中OPG/RANKL、炎症因子水平。 |
| 英文摘要: |
| To study the anesthetic effect of buprenorphine transdermal patch in elderly patients undergoing hip replacement and its effect on Osteoprotegerin/Receptor Activator of Nuclear Factor-κ B Ligand(OPG/RANKL)and inflammatory factors. 80 patients were divided into two groups according to different drugs, control group (n=40) and observation group (n=40). The patients in the control group were given celecoxib (20 mg/time, twice a day). The patients in the observation group were given buprenorphine transdermal patch (5 mg). The results showed that there was no significant difference in Visual Analogue Scale(VAS)score between the two groups at 4,16 and 1 day after operation. The VAS score of the observation group was significantly lower than that of the control group 2 and 7 days after operation (P<0.05). The OPG of the two groups increased significantly, while the levels of RANKL and inflammatory factors C reactive protein, (CRP), Homocysteine(Hcy), Interleukin 1β(IL1β)decreased significantly (P<0.05). The changes of the above indexes in the observation group were more obvious than those in the control group (P<0.05). So Buprenorphine transdermal patch has a long-term anesthetic effect in elderly patients undergoing hip replacement, and can significantly reduce the levels of OPG/RANKL and inflammatory factors in serum. |
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