张萍,刘文培,林应标,代国知,郭旺源,江杨华,唐萍,张健,瞿小旺,罗迪贤.HCV与HBV共感染影响血清HBV核酸与表面抗原水平.[J].中南医学科学杂志.,2019,(6):643-647.
HCV与HBV共感染影响血清HBV核酸与表面抗原水平
HCV coinfection with HBV impact the level of nucleic acid and HBsAg of HBV in serum
投稿时间:2019-08-14  修订日期:2019-10-16
DOI:10.15972/j.cnki.43-1509/r.2019.06.021
中文关键词:  乙型肝炎病毒  丙型肝炎病毒  共感染  表面抗原  病毒载量
英文关键词:hepatitis B virus  hepatitis C virus  coinfection  HBsAg  viral load
基金项目:
作者单位
张萍 南华大学附属郴州医院转化医学研究所,湖南 郴州 423000 
刘文培 南华大学附属郴州医院转化医学研究所,湖南 郴州 423000 
林应标 郴州市第一人民医院检验医学中心,湖南 郴州 423000 
代国知 郴州市第一人民医院检验医学中心,湖南 郴州 423000 
郭旺源 郴州市第一人民医院检验医学中心,湖南 郴州 423000 
江杨华 郴州市第一人民医院检验医学中心,湖南 郴州 423000 
唐萍 南华大学附属郴州医院转化医学研究所,湖南 郴州 423000 
张健 南华大学附属郴州医院转化医学研究所,湖南 郴州 423000 
瞿小旺 南华大学附属郴州医院转化医学研究所,湖南 郴州 423000 
罗迪贤 南华大学附属郴州医院转化医学研究所,湖南 郴州 423000 
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中文摘要:
      分析和评估HCV与HBV共感染对HBV临床指征的影响。采集152例有静脉吸毒史HBV感染者血浆,其中HBV/HCV共感染组52例,HBV单感染组100例。检测分析包括ALT和AST、HBV表面抗原(HBsAg)、e抗原、e抗体、HBV DNA及anti-HCV IgG与HCV RNA。结果显示,两组样本的ALT和AST水平无显著差异(P=0.097, P=0.184);HBV/HCV共感染组HBsAg水平显著低于HBV单感染组HBsAg水平(P=0.020);共感染组HBV DNA阳性率显著低于HBV单感染组HBV DNA阳性率(P=0.004),且共感染组中HBV DNA载量也显著低于HBV单感染组HBV DNA载量(P=0.031)。进一步分析发现:在HBV单感染患者中的HBV DNA和HBsAg具有良好的正相关关系(r=0.752, P<0.001),但在HBV/HCV共感染患者中相关性减弱(r=0.387, P=0.042)。本研究显示HCV共感染可能与HBV存在竞争关系,从而影响HBV病毒复制水平及表面抗原分泌。
英文摘要:
      To analyze and evaluate the effect of HCV coinfection on clinical indicators of HBV-infected patients. 152 individuals with HBV infection from intravenous drug users were enrolled. 52 individuals were HBV/HCV co-infected and 100 individuals were mono-HBV infection. Serum ALT and AST, HBsAg, HBeAg, anti-HBe, HBV DNA and anti-HCV IgG, HCV RNA were measured. The results showed that there was no significant difference in ALT and AST levels between the two groups (P=0.097, P=0.184); The positive rate of HBV DNA in the co-infection group was lower (P=0.004) compared with mono-HBV infection, and the HBsAg level and HBV DNA load in co-infection group were lower than those of mono-HBV infection (P=0.020, P=0.031); there was a positive correlation between HBV DNA and HBsAg in mono-HBV infected individuals (r=0.752, P<0.001), but the correlation is weakened in coinfected individuals(r=0.387, P=0.042). The results of this study suggested HCV coinfection significantly impact HBV replication and HBsAg secretion, which may indicate that HCV coinfection interfere with HBV replication.
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