许侃,胡光菊.银杏叶提取物对老年血管性痴呆患者认知功能及血液流变学参数的影响.[J].中南医学科学杂志.,2019,(6):621-624.
银杏叶提取物对老年血管性痴呆患者认知功能及血液流变学参数的影响
Effect of ginkgo biloba extract on cognitive function and hemorheology in elderly patients with vascular dementia
投稿时间:2019-04-12  修订日期:2019-08-09
DOI:10.15972/j.cnki.43-1509/r.2019.06.015
中文关键词:  银杏叶提取物  盐酸多奈哌齐  血管性痴呆  认知功能  血液流变学  C反应蛋白
英文关键词:ginkgo biloba extract  donepezil hydrochloride  vascular dementia  cognitive function  hemorheology  c-reactive protein
基金项目:
作者单位
许侃 宜昌市优抚医院老年病科,湖北 宜昌443002 
胡光菊 宜昌市中心医院老年病科,湖北 宜昌 443000 
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中文摘要:
      例老年血管性痴呆患者按照不同治疗方法分为对照组(n=50)和观察组(n=50),对照组患者采用盐酸多奈哌齐治疗,观察组患者采用银杏叶提取物联合盐酸多奈哌齐治疗。治疗结果显示,两组患者经治疗后认知功能项目评分均明显升高(P<0.05),血清中C反应蛋白(CRP)、脑钠肽(BNP)、神经元特异性烯醇化酶(NSE)、中枢神经特异性蛋白(S100β)和β-淀粉样蛋白(Aβ)水平均明显降低(P<0.05),血液流变学参数血浆黏度、全血高切黏度和全血低切黏度及红细胞沉降率水平均明显降低(P<0.05),且与对照组相比,观察组患者的上述指标变化更显著(P<0.05)。实验表明,银杏叶提取物联合盐酸多奈哌齐能有效改善老年血管性痴呆患者认知功能,降低血清认知功能相关因子及血液流变学参数水平。
英文摘要:
      elderly patients with vascular dementia were divided into two groups according to the treatment method. The control group (n=50) was treated with donepezil hydrochloride, while the observation group (n=50) was treated with Ginkgo biloba extract combined with donepezil hydrochloride. The results showed that After treatment, the scores of cognitive function items in both groups were significantly increased (P<0.05), and the levels of CRP, BNP, NSE, S100 beta and A beta in serum were significantly decreased (P<0.05). The blood rheological parameters such as plasma viscosity, whole blood high shear viscosity and whole blood low shear viscosity as well as ESR were decreased significantly after treatment (P<0.05). Compared with the control group, the changes of the above indexes in the observation group were more significant (P<0.05). So Ginkgo biloba extract combined with donepezil hydrochloride can effectively improve the cognitive function of elderly patients with vascular dementia, and reduce the level of serum cognitive function related factors and hemorheological parameters.
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