曹金凤,靳乐,蒋留琴,鲁彦斌,李鹤云,王永祥.瑞芬太尼复合丙泊酚麻醉对颅脑手术患者认知功能及炎症反应的影响分析.[J].中南医学科学杂志.,2019,(6):613-616.
瑞芬太尼复合丙泊酚麻醉对颅脑手术患者认知功能及炎症反应的影响分析
Effect of remifentanil combined with propofol anesthesia on cognitive function and inflammatory response in patients undergoing craniocerebral surgery
投稿时间:2019-04-02  修订日期:2019-06-03
DOI:10.15972/j.cnki.43-1509/r.2019.06.013
中文关键词:  瑞芬太尼  丙泊酚  麻醉  颅脑手术  认知功能  炎症反应
英文关键词:remifentanil  propofol  anesthesia  craniocerebral surgery  cognitive function  inflammatory response
基金项目:
作者单位
曹金凤 陕西省核工业二一五医院 麻醉科,陕西 咸阳 712000 
靳乐 陕西省核工业二一五医院 麻醉科,陕西 咸阳 712000 
蒋留琴 陕西省核工业二一五医院 麻醉科,陕西 咸阳 712000 
鲁彦斌 陕西省核工业二一五医院 麻醉科,陕西 咸阳 712000 
李鹤云 陕西省核工业二一五医院 重症医学科,陕西 咸阳 712000 
王永祥 陕西省核工业二一五医院 麻醉科,陕西 咸阳 712000 
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中文摘要:
      例颅脑手术患者分别采用瑞芬太尼(对照组,n=83)和瑞芬太尼复合丙泊酚(观察组,n=88)进行麻醉。比较两组患者麻醉前后认知功能评分和炎症反应因子NSE等水平的变化。结果显示对照组和观察组患者麻醉后记忆力评分、定向力评分、注意力和计算力评分、语言能力评分和回忆能力评分均明显降低(P<0.05),麻醉后血清中NSE、S-100β、IL1β、IL2及IL6水平均明显升高(P<0.05),且对照组患者的变化程度更明显(P<0.05)。实验结果证明瑞芬太尼复合丙泊酚麻醉后颅脑手术患者认知功能评分明显降低而炎症因子水平明显升高,但变化幅度低于单独采用瑞芬太尼组患者。
英文摘要:
      patients underwent craniocerebral surgery anesthesia remifentanil (control group, n=83) and remifentanil combined with propofol (observation group, n=88) respectively . The changes of cognitive function score before and after anesthesia were analyzed. The levels of NSE, S-100beta, IL-1beta, IL-2 and IL-6 in serum were measured by ELISA. The results showed that after anesthesia, the scores of memory, orientation, attention and calculation, language ability and recall ability of the patients in the control group and the observation group were significantly decreased (P<0.05). The levels of NSE, S-100beta, IL-1beta, IL-2 and IL-6 in serum increased significantly after anesthesia (P<0.05). The degree of change in the control group was more obvious (P<0.05). After remifentanil combined with propofol anesthesia, the cognitive function score of patients undergoing craniocerebral surgery decreased significantly, while the level of inflammatory factors increased significantly. But the range of change was lower than that of remifentanil alone group.
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