熊芮,樊丹丹,薛贵方.血液透析滤过联合左卡尼汀对老年肾病血液透析患者肝肾功能指标及贫血的影响.[J].中南医学科学杂志.,2019,(6):610-612, 616.
血液透析滤过联合左卡尼汀对老年肾病血液透析患者肝肾功能指标及贫血的影响
Effect of hemodiafiltration combined with Levocarnitine on liver and kidney function and anemia in elderly nephrotic patients undergoing hemodialysis
投稿时间:2019-07-10  修订日期:2019-10-15
DOI:10.15972/j.cnki.43-1509/r.2019.06.012
中文关键词:  血液透析  滤过  左卡尼汀  肾功能  贫血
英文关键词:hemodialysis  filtration  levocarnitine  renal function  anemia
基金项目:
作者单位
熊芮 四川大学华西医院肾脏内科,四川 成都610000 
樊丹丹 四川大学华西医院肾脏内科,四川 成都610000 
薛贵方 四川大学华西医院肾脏内科,四川 成都610000 
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中文摘要:
      分析血液透析滤过联合左卡尼汀对老年肾病血液透析患者肝肾功能指标及贫血的影响。将100例老年肾病血液透析患者分为对照组(n=50)和观察组(n=50)。对照组患者接受血液透析滤过治疗,观察组患者接受血液透析滤过联合左卡尼汀治疗。结果显示两组患者治疗后血尿酸氮(BUN)及肌酐(Cr)水平均明显降低(P<0.05)而红细胞计数、血红蛋白及红细胞比容水平均明显升高(P<0.05),且与对照组相比,观察组患者上述指标升高更显著(P<0.05),两组患者治疗后肝功能指标总胆红素(TBIL)、谷草转氨酶(AST)及谷丙转氨酶(ALT)水平均无明显变化(P>0.05)。观察组患者的不良反应发生率明显低于对照组(P<0.05)。实验表明,血液透析滤过联合左卡尼汀对老年肾病血液透析患者肾功能及贫血有明显的改善作用,且不良反应发生率明显低于单独使用血液透析滤过。
英文摘要:
      To study the effects of hemodiafiltration combined with Levocarnitine on liver and kidney function and anemia in elderly patients with nephrotic hemodialysis. 100 patients were randomly divided into two groups, control group (n=50) and observation group (n=50). The control group received hemodiafiltration treatment. Patients in the observation group received hemodiafiltration combined with Levocarnitine treatment. The results showed that After treatment, BUN and Cr levels were significantly decreased in both groups (P<0.05),while erythrocyte count, hemoglobin and specific volume of erythrocyte were significantly increased (P<0.05). Compared with the control group, the above indexes in the observation group increased more significantly (P<0.05). There were no significant changes in TBIL, AST and ALT levels after treatment in both groups (P>0.05). The incidence of adverse reactions in the observation group was significantly lower than that in the control group (P<0.05). Hemodiafiltration combined with Levocarnitine can significantly improve renal function and anemia in elderly patients with nephrotic hemodialysis, and the incidence of adverse reactions is significantly lower than that of hemodiafiltration alone.
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