| 王钊,彭林涛,杨帆,栗斌.腹腔镜结直肠癌根治术对患者凝血功能因子、体质量及内质网应激反应蛋白水平的影响.[J].中南医学科学杂志.,2019,(5):499-502. |
| 腹腔镜结直肠癌根治术对患者凝血功能因子、体质量及内质网应激反应蛋白水平的影响 |
| Effect of laparoscopic radical resection of colorectal cancer on coagulation function factor, body mass and endoplasmic reticulum stress response protein level |
| 投稿时间：2019-05-09 修订日期：2019-08-09 |
| DOI：10.15972/j.cnki.43-1509/r.2019.05.014 |
| 中文关键词: 腹腔镜 结直肠癌根治术 凝血功能 体质量 内质网应激 术中出血量 住院时间 术后排气时间 |
| 英文关键词:laparoscopy radical resection of colorectal cancer coagulation function body mass endoplasmic reticulum stress intraoperative bleeding hospitalization time postoperative exhaust time |
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| 中文摘要: |
| 分析腹腔镜结直肠癌根治术对患者的综合疗效,将130例患者按照不同的治疗方法分为两组:对照组(n=65)患者接受常规的开腹结直肠癌根治术治疗,观察组(n=65)患者接受腹腔镜结直肠癌根治术治疗。结果显示观察组患者的术中出血量、住院时间、术后排气时间及导尿管留置时间均明显降低(P<0.05)而手术时间明显延长(P<0.05),体质量增加患者和体质量不变患者的比例明显升高(P<0.05),两组患者术后内质网应激反应蛋白肌醇需求酶I(REl)、活化转录因子6(ATF6)及蛋白激酶样内质网激酶(PERK)水平均明显升高(P<0.05),且对照组患者的上述指标变化比观察组患者更明显(P<0.05),而凝血因子相关指标部分凝血活酶时间(APTT)、血浆凝血酶原时间(PT)、血小板及纤维素原(FIB)、凝血酶时间(TT)及血小板(PLT)水平均无明显变化(P>0.05)。实验表明,腹腔镜结直肠癌根治术患者围术期指标优于常规的开腹结直肠癌根治术,对患者的内质网应激刺激小且不影响凝血功能相关因子水平。 |
| 英文摘要: |
| To investigate the effects of laparoscopic radical resection of colorectal cancer. 130 cases were divided into two groups according to the treatment method. The control group (n=65) received routine open radical resection for colorectal cancer. The observation group (n=65) received laparoscopic radical resection of colorectal cancer. The results showed that the bleeding volume, hospital stay, exhaust time and indwelling time of catheter in the observation group were significantly reduced (P<0.05), while the operation time was significantly prolonged (P<0.05). In the observation group, the proportion of patients with increased body mass and those with unchanged body mass increased significantly (P<0.05).The levels of IREL, ATF6 and PERK in endoplasmic reticulum were significantly increased in both groups (P<0.05). The changes of the above indexes in the control group were more obvious than those in the observation group (P<0.05). There were no significant changes in PT, APTT, TT, FIB and PLT levels before and after treatment in both groups (P>0.05). So The perioperative indicators of laparoscopic radical resection of colorectal cancer are better than those of conventional open radical resection of colorectal cancer. The endoplasmic reticulum stress stimulation of patients is small and does not affect the level of coagulation related factors. |
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