| 刘曙艳,周雪红,李勇峰.沙格列汀联合二甲双胍对新诊断2型糖尿病患者血清炎症因子及胰岛β细胞功能的影响分析.[J].中南医学科学杂志.,2019,(5):496-498, 541. |
| 沙格列汀联合二甲双胍对新诊断2型糖尿病患者血清炎症因子及胰岛β细胞功能的影响分析 |
| Effect of sagliptin and metformin on serum inflammatory factor and islet beta cell function in newly diagnosed Type 2 Diabetes Mellitus |
| 投稿时间：2019-04-12 修订日期：2019-07-06 |
| DOI：10.15972/j.cnki.43-1509/r.2019.05.013 |
| 中文关键词: 沙格列汀 2型糖尿病 炎症因子 β细胞功能 胰岛素抵抗 |
| 英文关键词:saglitine metformin type 2 diabetes mellitus leptin beta cell function insulin resistance |
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| 中文摘要: |
| 将2型糖尿病患者共80例分为对照组(n=40)和观察组(n=40),对照组患者给予二甲双胍治疗,观察组患者给予沙格列汀联合二甲双胍治疗。两组患者治疗后空腹及餐后2小时血糖、肿瘤坏死因子-α(TNF-a)水平较治疗前均明显降低(P<0.05),可溶性类肿瘤坏死因子细胞凋亡弱诱导剂(sTWEAK)较治疗前明显升高(P<0.05),且对照组与观察组患者治疗后血糖控制指标及炎症因子间差异有显著性(P<0.05),且观察组患者的糖化血红蛋白达标率更高；两组患者治疗后胰岛素抵抗指数(HOMA-IR)水平均明显降低(P<0.05)而胰岛β细胞功能指数(HOMA-β)明显升高(P<0.05),且与对照组患者相比,观察组患者的上述指标变化更显著(P<0.05)。因此,沙格列汀联合二甲双胍可以纠正新诊断2型糖尿病患者炎症因子水平、改善胰岛β细胞功能,有效控制血糖。 |
| 英文摘要: |
| Type 2 diabetes patients were divided into two groups according to the treatment method:control group (n=40) and observation group (n=40). The patients in the control group were treated with melbine, while the patients in the observation group were treated with sagliptin and metformin. The results showed that the levels of fasting blood glucose, Tumor Necrosis Factor-α(TNF-a) andsolubleTNF-likeweakinducerofapoptosis(sTWEAK) in the two groups were significantly lower than those before treatment (P<0.05), and significantly higher than those before treatment (P<0.05). Compared with the control group, there were significant differences in blood sugar control indicators and inflammatory factors after treatment in the observation group (P<0.05), and the rate of glycosylated hemoglobin reaching the standard was higher. After treatment, the levels of Homeostasis model assessment(HOMA-IR) in the control group and the observation group decreased significantly (P<0.05), while index of β-cell function in HOMA(HOMA-beta) increased significantly (P<0.05). Compared with the control group, the changes of the above indexes in the observation group were more significant (P<0.05). So Sagliptin combined with metformin can effectively reduce leptin level and improve islet beta cell function in newly diagnosed type 2 diabetes mellitus. |
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