| 曹海燕,吕学东,顾俊.亚硝酸钠对大鼠高肺血流肺动脉高压的治疗作用及可能机制.[J].中南医学科学杂志.,2019,(5):492-495. |
| 亚硝酸钠对大鼠高肺血流肺动脉高压的治疗作用及可能机制 |
| Therapeutic effect of NaNO2 on rat pulmonary hypertension induced by high pulmonary blood flow and the underlyingexperimental mechanism |
| 投稿时间：2018-11-21 修订日期：2019-08-15 |
| DOI：10.15972/j.cnki.43-1509/r.2019.05.012 |
| 中文关键词: 亚硝酸钠 肺动脉高压 肺血流 大鼠 |
| 英文关键词:sodium nitrite pulmonary hypertension high pulmonary blood flow rat |
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| 中文摘要: |
| 探讨亚硝酸钠(NaNO2)对肺动脉高压大鼠的血流动力学改善效果及其作用机制。采用清洁级成年SD雄性大鼠通过腹主动脉-下腔静脉分流手术,建立高肺血流肺动脉高压大鼠模型,对照组(仅采取假手术)。治疗组给予NaNO2灌胃(3 mg/kg,1次/天,连续3周),模型组和对照组仅给予等量生理盐水灌胃；对比各组的心肺功能及血浆、肺组织中NO水平和肺组织中NF-κB、TGF-β1、VEGF蛋白的表达。结果显示,与模型组和对照组相比,NaNO2干预3周后,治疗组大鼠的肺血流、肺动脉压具有显著的降低作用,并可减轻肺动脉血管及右心脏重构,其作用机制可能与降低肺组织中NF-κB、TGF-β1、VEGF及增高NO水平有关。 |
| 英文摘要: |
| To investigate the therapeutic effect of NaNO2 on pulmonary hypertension rats(PHA) and the underlying mechanism. PHA rats were established by abdominal aorta-inferior vena cava shunt surgery. The control rats were subjected to sham operation. The PHA rats (treatment group) was given by gavage of NaNO2 for 3 weeks(3mg/kg, q.d), the rats in the model group and the control group were given the same amount of normal saline. The function of heart and pulmonary were improved, the level of NO, and the expression of NF-κB, TGF-β1 and VEGF in the lung tissues were compared between the three groups. The results showed that 3 weeks of treatment with NaNO2 had a significant alleviated dynamics of pulmonary blood, blood pressure in rats, and the pulmonary vascular and right ventricular remodeling, the underlying mechanism may be related to the down-regulation the levels of NF-κB, TGF-β1, VEGF and increase of NO in lung tissue. |
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