| 孙瑞雪,姜泓,张宁梅,雷娟娟.血清Copeptin、HIF-1α、CT-1水平与新生儿败血症心肌损伤的相关性分析.[J].中南医学科学杂志.,2019,(5):462-464. |
| 血清Copeptin、HIF-1α、CT-1水平与新生儿败血症心肌损伤的相关性分析 |
| Correlation analysis of serum copeptin, HIF-1α, CT-1 levels and myocardial injury in neonatal septicemia |
| 投稿时间：2019-01-31 修订日期：2019-04-22 |
| DOI：10.15972/j.cnki.43-1509/r.2019.05.004 |
| 中文关键词: 和肽素 缺氧诱导因子-1α 心肌营养素1 新生儿败血症 |
| 英文关键词:copeptin hypoxia inducible factor-1α myocardial nutrition-1 neonatal septicemia |
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| 中文摘要: |
| 探讨新生儿败血症和肽素(Copeptin)、缺氧诱导因子-1α(HIF-1α)、心肌营养素1(CT-1)水平与心肌损伤的相关性。选取本院收治的150例新生儿败血症患儿分为心肌损伤组(n=82)和非心肌损伤组(n=68)。比较各组间血清Copeptin、HIF-1α、CT-1水平。结果显示,与非心肌损伤组比较,心肌损伤组血清肌酸激酶心肌同工酶(CK-MB)、心肌肌钙蛋白I(cTnI)和心脏型脂肪酸结合蛋白(H-FABP)水平,血清Copeptin、HIF-1α、CT-1水平显著升高(P<0.05)。经过Spearson相关性分析,Copeptin、HIF-1α、CT-1水平与新生儿败血症合并心肌损伤患儿CK-MB、cTnI、H-FABP均呈正相关(P<0.05)。结果提示,血清Copeptin、HIF-1α、CT-1水平对患儿的病情评估和预后有潜在临床价值。 |
| 英文摘要: |
| To investigate the correlation between copeptin, hypoxia inducible factor-1α (HIF-1α), myocardial nutrient 1 (CT-1) and myocardial injury. The subjects of150 neonates with septicemia were selected and divided into two groups:myocardial injury group (n=82) and non-myocardial injury group (n=68). The serum levels of Copeptin, HIF-1α and CT-1 and the markers of cardiac function injury were compared in each group. The serum CK-MB, cTnI, H-FABP level in myocardial injury group were significantly higher than that in non myocardial injury group (P<0.05). The serum levels of Copeptin, HIF-1α and CT-1 in myocardial injury group were significantly higher than those in non myocardial injury group (P<0.05). By Spearson correlation analysis, the levels of Copeptin, HIF-1 α and CT-1 were positively correlated with CK-MB, cTnI, H-FABP in neonates with septicemia and myocardial injury (P<0.05). The levels of serum Copeptin, HIF-1 α and CT-1 have potential clinical value for the evaluation and prognosis of neonatal septicemia. |
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