| 李承秋,吕文艺,吴玉兰.GnRH-α与反向添加疗法减轻子宫内膜异位症患者疼痛的机制.[J].中南医学科学杂志.,2019,(4):407-410. |
| GnRH-α与反向添加疗法减轻子宫内膜异位症患者疼痛的机制 |
| Mechanism of reducing pain of GnRH-α and reverse addition therapy on endometriosis patients |
| 投稿时间：2018-10-06 修订日期：2019-06-03 |
| DOI：10.15972/j.cnki.43-1509/r.2019.04.018 |
| 中文关键词: 促性腺激素释放激素激动剂 反向添加疗法 子宫内膜异位症 糖类抗原125 肿瘤坏因子-α 白细胞介素-18 |
| 英文关键词:Gonadotropin-releasing hormone agonist reverse additive endometriosis carbohydrate antigen TNF-α IL-18 |
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| 中文摘要: |
| 探讨促性腺激素释放激素激动剂(GnRH-α)与反向添加疗法治疗子宫内膜异位症(EMS)对患者生殖激素、血清糖类抗原125(CA125)、肿瘤坏因子-α(TNF-α)、白细胞介素-18(IL-18)水平的影响。比较患者治疗前后血清雌二醇(E2)、卵泡刺激素(FSH)、黄体生成素(LH)、糖类抗原(CA125)、肿瘤坏因子-α(TNF-α)、白细胞介素-18(IL-18)、视觉模拟疼痛评分(VAS评分)、更年期症状评分(Kupperman评分)。结果显示,GnRH-α与反向添加疗法治疗后,患者血清E2水平升高；血清TNF-α、IL-18水平降低；VAS评分、Kupperman评分降低。本研究表明,GnRH-α联合反向添加疗法治疗EMS患者较单纯使用GnRH-α治疗有利于维持雌激素水平、进一步减轻疼痛及围绝经期症状。 |
| 英文摘要: |
| To investigate the effects of gonadotropin-releasing hormone agonist (GnRH-α) and reverse-addition therapy on endometriosis (EMS) in patients with reproductive hormone, serum carbohydrate antigen 125 (CA125), tumor-derived factor-α (TNF- The effects of α) and interleukin-18 (IL-18) levels. Serum estradiol (E2), follicle stimulating hormone (FSH), luteinizing hormone (LH), carbohydrate antigen (CA125), tumor-derived factor-α (TNF- α), interleukin-18 (IL-18), visual analogue pain score (VAS score) and menopausa symptom score (Kupperman score) were compared before and after treatment. Results showed that after treatment with GnRH- α and reverse -addition therapy, serum E2 level increased, serum TNF- α -IL-18 level decreased and Kupperman score decreased. Although GnRH-α combined with reverse addition therapy in patients with EMS is more effective than GnRH-α alone in maintaining estrogen levels, further reducing pain and perimenopausal symptoms. |
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