宋亚男,朱蓓,高飞,张娟,张宇,赵卫红.羟苯磺酸钙对肌氨酸氧化酶法评估肾功能的影响.[J].中南医学科学杂志.,2019,(3):250-254.
羟苯磺酸钙对肌氨酸氧化酶法评估肾功能的影响
Effect of calcium dobesilate on renal function assessment by creatine oxidase assay
投稿时间:2019-03-04  修订日期:2019-03-31
DOI:10.15972/j.cnki.43-1509/r.2019.03.006
中文关键词:  慢性肾脏病  羟苯磺酸钙  肾功能  肌氨酸氧化酶法
英文关键词:chronic kidney disease  calcium dobesilate  renal function  sarcosine oxidase assay
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作者单位
宋亚男 南京医科大学第一附属医院老年肾科,江苏 南京 210029 
朱蓓 南京医科大学第一附属医院老年肾科,江苏 南京 210029 
高飞 南京医科大学第一附属医院老年肾科,江苏 南京 210029 
张娟 南京医科大学第一附属医院老年肾科,江苏 南京 210029 
张宇 南京医科大学第一附属医院老年肾科,江苏 南京 210029 
赵卫红 南京医科大学第一附属医院老年肾科,江苏 南京 210029 
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中文摘要:
      探讨羟苯磺酸钙对肾功能评估的影响。把31例肾功能不全患者按照慢性肾脏病(CKD)分类标准分为:CDK1-2, CKD3-4 和CKD5三组,并给予7天羟苯磺酸钙治疗,检测治疗前后不同肾功能水平肌酐(Cr)、血清胱抑素(CysC)、尿素(Urea)、肾小球滤过率(eGFR)变化。结果显示,羟苯磺酸钙对肌氨酸氧化酶法测定Cr有干扰作用。在CKD3-5期患者中,羟苯磺酸钙对肌氨酸氧化酶法测定Cr及eGFRCKD-EPI2012Cr-CysC、eGFRCKD-EPI2009Scr公式评估肾功能有明显干扰,而对CysC、Urea及eGFRCKD-EPI2012cys无影响,故临床上对于服用羟苯磺酸钙者使用CKD-EPI2012cys公式评估肾功能更为准确。
英文摘要:
      To investigate the effect of calcium dobesilate on the assessment of renal function. A total of 31 patients were divided into CDK1-2 group, CKD3-4 group and CKD5 group according to the renal function level. All groups were treated with calcium dobesilate for 7 days, creatinine (Cr), serum cystatin (CysC),blood urea nitrogen(Urea) and glomerular filtration rate were compared at time points of before and post-treatment. Results show that after taking calcium dobesilate, there was a significant changes of Cr by the method of sarcosine oxidase assay. In nonclusion, in patients with CKD 3-5 stage, calcium dobesilate has significant interference in the detection of Cr, eGFRCKD-EPI2012Cr-CysC and eGFRCKD-EPI2009Scr, but has no effect on CysC, Urea and eGFRCKD-EPI2012CysC. Therefore, it is more accurate to use the CKD-EPI2012cys formula for patients taking calcium dobesilate to evaluate renal function.
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