| 李响,宁倩,戴诗琴,唐圣松.转录因子KLF5在恶性肿瘤发生中作用的研究进展.[J].中南医学科学杂志.,2019,(3):225-229. |
| 转录因子KLF5在恶性肿瘤发生中作用的研究进展 |
| Role of transcription factor KLF5 in tumorigenesis |
| 投稿时间：2019-02-25 修订日期：2019-03-30 |
| DOI：10.15972/j.cnki.43-1509/r.2019.03.001 |
| 中文关键词: Krüppel样因子5 恶性肿瘤 环境依赖性 微RNA |
| 英文关键词:KLF5 tumor context-dependent microRNA |
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| 中文摘要: |
| Krüppel样因子5(KLF5)是一种能与DNA结合的锌指转录调节因子,其在乳腺癌、前列腺癌、结直肠癌和肺癌等多种恶性肿瘤中的作用具有环境依赖性。微RNA和长链非编码RNA可以调控KLF5的表达。同时KLF5也可以调控众多的下游靶基因的表达。本文主要介绍了KLF5在恶性肿瘤中的作用,也分析了在不同的细胞状态下通过调节KLF5蛋白的水平而影响下游基因表达的机制差异。深入研究这些差异性或能进一步揭示KLF5在肿瘤发生发展中的作用规律。 |
| 英文摘要: |
| Krüppel-like factor 5 (KLF5) is a DNA-binding transcriptional regulator which plays an important role in most tumors. The functions of KLF5 are context-dependent in breast cancer, prostate cancer, colorectal cancer and lung cancer. It can be regulated by microRNAs and non-coding RNAs. It can also regulate the expression of many downstream target genes. This article presents the differential roles of KLF5 in different cancers, and the mechanisms by which these differences are affected through the regulation of KLF5 protein function in response to different cellular states and the direct effect on downstream genes expression. Exploring these differences is likely to be important in discoveries and new research ideas about KLF5. |
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