肖维霞,马金珠.监测血清β-hCG下降时间用于指导妊娠滋养细胞疾病化疗方案的意义.[J].中南医学科学杂志.,2019,(1):61-63.
监测血清β-hCG下降时间用于指导妊娠滋养细胞疾病化疗方案的意义
Clinical efficacy of monitoring serum beta-hCG fall time in guiding chemotherapy regimens for gestational trophoblastic disease
投稿时间:2018-08-29  修订日期:2018-10-24
DOI:10.15972/j.cnki.43-1509/r.2019.01.016
中文关键词:  滋养细胞疾病  下降时间  血清β-hCG  化疗方案  临床效果
英文关键词:trophoblastic diseases  falling time  beta hCG serum  chemotherapy regimens  clinical effects
基金项目:
作者单位
肖维霞 云南省中医学院第二附属医院妇产科,云南 昆明 650041 
马金珠 云南省中医学院第二附属医院检验科,云南 昆明 650041 
摘要点击次数: 560
全文下载次数: 483
中文摘要:
      分析血清β-hCG下降时间指导妊娠滋养细胞疾病(GTD)化疗的意义。选择GTD化疗患者,分析患者β-hCG及经阴道多普勒超声检查结果。GTD良性组在化疗前及前2个疗程化疗阶段,血清β-hCG水平均显著低于GTD恶性组;GTD良性组与恶性组不同化疗阶段血清β-hCG水平总体呈下降趋势,且不同疗程之间的血清β-hCG水平均存在统计学差异;不同化疗疗程阶段血清β-hCG与PSV、EDV水平总体呈负相关,与阻力指数则总体呈正相关。本研究认为血清β-hCG下降时间与其接受化疗的周期和取得的疗效均存在较好的相关性,因此监测血清β-hCG下降时间用于指导GTD化疗方案具有一定的可行性。
英文摘要:
      it is to analyze the significance of serum-hCG decrease in guiding gestational trophoblastic disease (GTD) chemotherapy. Patients with GTD chemotherapy were selected to analyze the results of beta-hCG and transvaginal Doppler ultrasound. The levels of serum beta-hCG in GTD benign group were significantly lower than those in GTD malignant group before and during the first two courses of chemotherapy; the levels of serum beta-hCG in GTD benign group and malignant group at different stages of chemotherapy showed a general downward trend, and the levels of serum beta-hCG in different courses of chemotherapy were statistically different. During the course of chemotherapy, serum beta-hCG was negatively correlated with PSV and EDV levels, and positively correlated with resisitant index. This study suggests that the time of serum beta-hCG decline is correlated with the cycle of chemotherapy and the efficacy of chemotherapy. Therefore, it is feasible to monitor the time of serum beta-hCG decline in GTD chemotherapy.
查看全文  查看/发表评论  下载PDF阅读器
关闭
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=3C06DB566315F8DC78C14CE21C0BF8061612CC47AC23AF967CE65C9848EE427EC6CCC1B5BA9A08C066A634C2CC0B51C5A986AD568D9259D20BD99A85889A6DC08662AAA86D92335668573472508E9EA7778DA65C64DE698CA41E2B7F3366D9BA5F16BF4FE9D52A6FB0EAFBAC609B929B9D3FEBB8B0C60843C6E40B8AE9215495&pcid=A9DB1C13C87CE289EA38239A9433C9DC&cid=BB33F1C95224820A&jid=6A20DF2A798996E24F064D5ECF83A153&yid=B6351343F4791CA3&aid=718972CDA3F0A594E62A781E136FFB27&vid=&iid=CA4FD0336C81A37A&sid=1D0FA33DA02ABACD&eid=E84BBBDDD74F497C&fileno=20190116&flag=1&is_more=0">