| 肖莉,传军,罗迪贤,李文,张佳,李凯,廖端芳.生殖细胞基因编辑与基因治疗的问题与展望——以CCR5基因为例.[J].中南医学科学杂志.,2019,(1):1-6. |
| 生殖细胞基因编辑与基因治疗的问题与展望——以CCR5基因为例 |
| Problems and prospects of gene editing and gene therapy in germ cells:take the CCR5 gene as an example |
| 投稿时间：2018-12-14 修订日期：2018-12-24 |
| DOI：10.15972/j.cnki.43-1509/r.2019.01.001 |
| 中文关键词: 基因编辑 人类免疫缺陷病毒 CCR5 基因治疗 |
| 英文关键词:gene editing human immunodeficiency virus CCR5 gene therapy |
| 基金项目: |
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| 中文摘要: |
| 医学科学研究和医学临床实践,需要遵守人类的国际准则和国家的具体法规。最近报道的基因编辑婴儿,是一起破坏人类医学伦理底线的非法行医事件的结果。本文以CCR5基因为例,探讨基于基因编辑或基因治疗受精卵的技术局限性和未来需要发展的技术路径。 |
| 英文摘要: |
| Medical research and clinical practice have to fully meet all national and international ethics and regulations. The recently reported gene editing twin girls violated current ethics and is resulted from illegal medical practice. Taking CCR5 gene as an example, this paper analyzed the genotypes of the CCR5 alleles and the limitations of current gene editing and gene therapy technologies applied in germ line. Finally, future technologies required by germ line gene therapy are illustrated. |
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