| 鲁科利,江青山,刘志锋,彭静,黄芳,周泉君.EHD2在喉鳞状细胞癌组织中的表达及其临床意义.[J].中南医学科学杂志.,2018,(6):653-656. |
| EHD2在喉鳞状细胞癌组织中的表达及其临床意义 |
| The expression and clinical significance of EHD2 in laryngeal squamous cell carcinoma (LSCC) |
| 投稿时间：2018-06-07 修订日期：2018-10-25 |
| DOI：10.15972/j.cnki.43-1509/r.2018.06.025 |
| 中文关键词: 喉 鳞状细胞癌 EHD2 Ki-67 免疫组化 |
| 英文关键词:larynx squamous cell carcinoma EHD2 Ki-67 immunohistochemistry |
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| 中文摘要: |
| 检测喉鳞癌组织中EHD2的表达情况,探讨其与喉鳞癌患者的临床病理特征的相关性,并探讨其和增殖细胞核抗原Ki-67表达的相关性。采用免疫组织化学法(SP法)检测50例喉鳞癌组织和50例声带息肉组织中EHD2、Ki-67的表达水平,分析EHD2表达水平与喉癌患者的临床相关参数和预后的关系,并分析EHD2和Ki-67表达水平的关系。结果显示喉鳞癌组织中EHD2表达水平低于声带息肉组织(P＜0.05),EHD2的表达与喉癌患者的肿瘤分化状况、淋巴结转移情况紧密相关(P＜0.05),与患者的性别、年龄、肿瘤范围和TNM分期无明显相关性(P＞0.05)。生存分析显示EHD2表达与喉癌患者预后关系密切,高表达组患者生存率高于低表达组(P＜0.01)。EHD2表达与Ki-67表达呈负相关(P<0.05)。EHD2在喉鳞癌组织中的低表达,其很可能作为一种抑癌因子参与抑制喉癌发生发展的过程,且EHD2低表达对喉癌患者的预后具有重要意义。 |
| 英文摘要: |
| To examine the expression of EHD2 in human laryngeal squamous cell carcinoma (LSCC) and investigate the relationship between its expression, clinical characteristics of LSCC and the cell proliferative factor Ki-67. Immunohistochemical method (SP) to was used detect the expression level of EHD2 and Ki-67 in 50 laryngeal squamous cell carcinoma and 50 laryngeal polyps, and the relationship between its expression, clinical pathological parameters and Ki-67 expression was analyzed. Analyze the relationship between EHD2 expression, clinical parameters and prognosis in patients with laryngocarcinoma. Immunohistochemical results showed the expression of EHD2 in laryngeal carcinoma was lower than in vocal polyps (P＜0.05). Moreover, the expression level of EHD2 protein in LSCC was significantly related to tumor differentiation, lymph node metastasis (P＜0.05), but not with gender, age, range and TNM stage of tumor (P＞0.05). Survival analysis showed the expression of EHD2 was closely related to the prognosis of patients with laryngeal cancer, high survival rate was higher than that of patients with low expression group (P＜0.01). The expression of EHD2 was negatively correlated with Ki-67 (P<0.05). EHD2 in laryngeal squamous cell carcinoma (LSCC) has low expression, which may inhibit laryngeal cancer as a tumor suppressor factor, and EHD2 expression is of great significance to the prognosis of laryngeal squamous carcinoma. |
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