| 叶波,叶斌.术后颅内感染相关危险因素及早期炎症指标表达特点分析.[J].中南医学科学杂志.,2018,(6):646-649. |
| 术后颅内感染相关危险因素及早期炎症指标表达特点分析 |
| Analysis of risk factors for intracranial infection after neurosurgery operation and characteristics of early imflamatory index expression |
| 投稿时间：2018-06-12 修订日期：2018-10-30 |
| DOI：10.15972/j.cnki.43-1509/r.2018.06.023 |
| 中文关键词: 颅内感染 危险因素分析 降钙素原 白细胞 C-反应蛋白 |
| 英文关键词:intracranial infection risk factor analysis PCT WBC CRP |
| 基金项目: |
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| 中文摘要: |
| 为了分析颅内感染术后临床特征和炎症反应指标表达特点,本研究以本院神经外科接受开颅手术425例神经系统疾患(合并颅内感染56例,无感染369例)为研究对象,用单因素分析法筛选、Logistic回归方程分析颅内感染发生危险因素,对比颅内感染与无感染患者间炎症反应指标表达差异。结果发现年龄≥50岁、GCS评分低、手术时间≥4h、后颅窝手术、术后脑脊液漏是颅内感染独立危险因素；未感染患者血清PCT、CRP、WBC显著低于感染组(P<0.05)。由此可见,神经外科术后颅内感染发生独立危险因素较多,联合检测PCT、CRP、WBC等有利于早期确诊。 |
| 英文摘要: |
| In order to analyze the clinical characteristics of intracranial infection and the expression of the inflammatory response after the neurosurgery operation, 425 cases of nervous system disease (56 cases with combined intracranial infection and 369 cases without infection) in our hospital were studied. The risk of intracranial infection was analyzed by single factor analysis and Logistic regression equation. The difference in inflammatory response between intracranial infection and non infected patients was observed. The results showed that the age of 50 years old, low GCS score, operation time more than 4h, posterior cranial fossa operation and cerebrospinal fluid leakage were independent risk factors for intracranial infection, and the serum PCT, CRP and WBC of uninfected patients were significantly lower than that of the infection group (P<0.05). Results indicated that there were many independent risk factors for postoperative intracranial infection in Department of neurosurgery. Combined detection of PCT, CRP and WBC is conducive to early diagnosis. |
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