张金蓉,张艺,熊甜甜,江泓.盐酸纳美芬联合亚低温对重症病毒性脑炎患儿临床疗效及血清炎性因子的影响.[J].中南医学科学杂志.,2018,(6):639-642.
盐酸纳美芬联合亚低温对重症病毒性脑炎患儿临床疗效及血清炎性因子的影响
Impact of nalmefene combined with mild hypothermia on clinical outcome and inflammatory factors in children with severe viral encephalitis
投稿时间:2018-06-10  修订日期:2018-08-23
DOI:10.15972/j.cnki.43-1509/r.2018.06.021
中文关键词:  盐酸纳美芬  亚低温  脑炎  炎性因子
英文关键词:nalmefene  mild hypothermia  encephalitis  inflammatory factors
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作者单位
张金蓉 三峡大学第三临床医学院,葛洲坝集团中心医院儿科湖北 宜昌 443002 
张艺 湖北省妇幼保健院儿科 
熊甜甜 三峡大学第三临床医学院,葛洲坝集团中心医院儿科湖北 宜昌 443002 
江泓 三峡大学第三临床医学院,葛洲坝集团中心医院儿科湖北 宜昌 443002 
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中文摘要:
      探究盐酸纳美芬联合亚低温治疗对重症病毒性脑炎患儿的临床疗效。 将80例重症病毒性脑炎患儿分为对照组和观察组(n=40),对照组给予常规治疗,观察组给予常规治疗的同时加用盐酸纳美芬联合亚低温治疗。结果显示,与对照组相比,观察组体温恢复正常时间、呕吐消失时间、抽搐控制的时间及住院天数明显缩短,显效率和总有效率显著增高,炎性因子指标明显改善,后遗症发病率显著降低。盐酸纳美芬联合亚低温治疗能够明显改善患者的临床疗效及减轻体内的炎症反应。
英文摘要:
      To investigate the clinical outcome of Nalmefene combined with mild hypothermia in the treatment of severe viral encephalitis. 80 children patients with severe viral encephalitis were divided into control group and observation group(n=40). Control group were treated with conventional treatment, and observation group were treated with conventional treatment and nalmefene combined with mild hypothermia. Compared to control group, the time of temperature returned to normal, disappearance of vomiting and convulsions, and hospitalization days in observation group were shorter, the significant efficiency and total efficiency were increased (P<0.05), meanwhile, the inflammatory factors were significantly improved, and the incidence of sequelae was significantly lower. In conclusion, Nalmefene combined with mild hypothermia can improve the clinical effect and reduce the inflammatory reaction in children patients with severe viral encephalitis.
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