| 李薇,魏毅.血塞通软胶囊联合阿托伐他汀应用于急性缺血性中风患者的疗效观察.[J].中南医学科学杂志.,2018,(4):405-407, 427. |
| 血塞通软胶囊联合阿托伐他汀应用于急性缺血性中风患者的疗效观察 |
| Clinical effects of Xuesaitong soft capsule combined with atorvastatin in treating stroke patient and the effect on the PCSK9 thereof |
| 投稿时间：2017-12-25 修订日期：2018-06-23 |
| DOI：10.15972/j.cnki.43-1509/r.2018.04.019 |
| 中文关键词: 血塞通软胶囊 阿托伐他汀 急性缺血性中风 疗效 PCSK9 |
| 英文关键词:Xuesaitong Soft Capsule atorvastatin acute ischemic stroke curative effect PCSK9 |
| 基金项目: |
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| 中文摘要: |
| 探讨血塞通软胶囊联合阿托伐他汀治疗急性缺血性中风患者的疗效以及对血清前蛋白转化酶枯草溶菌素9(PCSK9)水平的影响。采用随机方法,收集80例急性缺血性中风(中经络)患者,随机分为观察组和对照组,每组40例。两组均采用常规西医治疗。对照组采用阿托伐他汀治疗,观察组在对照组的基础上加用血塞通软胶囊。 结果显示,治疗组总有效率为90%。对照组总有效率为70%。治疗组临床疗效明显优于对照组(P＜0.05)。两组药物均能显著降低急性缺血性脑卒中患者的血清总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平,提高高密度脂蛋白胆固醇水平(P＜0.01),观察组优于对照组(P＜0.05)。两组血清PCSK99水平比治疗前升高(P＜0.01)。与对照组相比,观察组血清PCSK9水平的改变有所降低(P＜0.05)。血塞通胶囊联合阿托伐他汀应用于急性缺血性中风患者疗效显著,血塞通软胶囊与他汀的联合使用具有叠加效应,并能升高PCSK9水平。 |
| 英文摘要: |
| To investigate clinical effects of Xuesaitong soft capsule combined with atorvastatin in treating stroke and the effect on PCSK9 thereof .80 cases of stroke patient were divided into the comprehensive treatment group and control group, 40 cases in each group. Both two groups were treated routinely with western medicine. Control group was given atorvastatin. Besides atorvastatin, patients in the comprehensive treatment group received Xuesaitong soft capsule. Results show that the total effective rate of the comprehensive treatment group was 87.5%, significantly higher than that of the control group (75%) (P<0.05). TC、TG、LDL-C、HDL-C in comprehensive treatment group were improved than that of control group (P<0.05). The level of serum PCSK9 increased in both two groups (P<0.05), and the change of that in the control group reduced. |
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