| 张红艳,欧元香,赖源.N末端前体脑钠肽在小儿脓毒症中的病情评估及临床意义.[J].中南医学科学杂志.,2018,(4):385-387. |
| N末端前体脑钠肽在小儿脓毒症中的病情评估及临床意义 |
| Disease Assessment and Clinical Significance of N-terminal Qian Natriuretic Peptide in Children with Sepsis |
| 投稿时间：2017-11-27 修订日期：2018-06-12 |
| DOI：10.15972/j.cnki.43-1509/r.2018.04.013 |
| 中文关键词: NT-proBNP 脓毒症 脓毒性休克 儿童 病情评估 |
| 英文关键词:NT-proBNP Sepsis Septic shock child Severity evaluation |
| 基金项目: |
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| 中文摘要: |
| 检测血浆N末端前体脑钠肽(NT-proBNP)值来判断小儿脓毒症的病情及预后的临床意义。选取本院儿童重症监护病房(PICU)的37例住院病人,均诊断为脓毒症(Sepsis),并记录小儿危重症(PCIS)评分、小儿死亡危险因素(PRISM Ⅲ)评分,依病情严重程度分为脓毒症组22例和脓毒性休克组15例,进行对比血浆NT-proBNP、降钙素原(PCT)值、预后关系；结果发现脓毒性休克组、死亡组PRISM Ⅲ及血浆NT-proBNP、PCT值明显升高,PCIS明显降低；根据患儿血浆NT-proBNP值可判断及评估小儿脓毒症的病情严重程度及预后,有利于指导临床早期实施有效干预措施。 |
| 英文摘要: |
| Detection of plasma N terminal pro brain natriuretic peptide (NT-proBNP) value was used to determine the clinical significance and prognosis of sepsis in children. 37 hospitalized patients in our pediatric intensive care unit (PICU) were selected. All of them were diagnosed as sepsis (Sepsis), and the score of children's critical disease (PCIS)and the risk factors of child death (PRISM III) score were recorded. According to the severity of illness, 22 cases of sepsis group and 15 cases of septic shock (Septic shock) group were divided into two groups, to compare plasma NT-proBNP, PCT value and prognosis.The results showed that the levels of PRISM III and NT-proBNP and PCT in septic shock group and death group increased significantly, while PCIS decreased significantly. According to the plasma NT-proBNP value of children, the severity and prognosis of sepsis in children can be determined and evaluated, which is conducive to guiding early clinical implementation of effective intervention measures. |
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