| 刘超,孟庆军,刘立红,刘城瑞,杨雪.胸腺瘤患者螺旋CT影像特征与CKP、VEGF表达的相关性研究.[J].中南医学科学杂志.,2018,(4):373-376. |
| 胸腺瘤患者螺旋CT影像特征与CKP、VEGF表达的相关性研究 |
| The correlation between thymoma spiral CT imaging features and the expression of CKP and VEGF |
| 投稿时间：2018-05-03 修订日期：2018-06-06 |
| DOI：10.15972/j.cnki.43-1509/r.2018.04.010 |
| 中文关键词: 胸腺瘤 螺旋CT CKP VEGF |
| 英文关键词:thymus tumor Spiral CT CKP VEGF |
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| 中文摘要: |
| 探讨胸腺瘤螺旋CT影像特征与细胞角蛋白(CKP)、血管内皮生长因子(VEGF)表达的相关性。回顾性分析本院收治的83例胸腺瘤患者的临床资料,总结胸腺瘤的影像学特征,并取患者手术病理切片采用免疫组化SP染色法检测CKP、VEGF的表达,分析CT影像特征和二者表达的相关性。结果显示CT增强幅度越大,VEGF阳性表达率越高,而CKP阳性表达率同CT的增强幅度无关。胸腺瘤CKP表达与病灶外观是否呈尖角或锯齿状、密度是否均匀、是否侵犯心包及胸膜和是否存在纵隔脂肪线存在相关性,而与外观是否呈分叶状、病灶直径、肺内是否转移无关。胸腺瘤VEGF表达与病灶外观是否呈尖角或锯齿状、是否呈分叶状、肺内是否转移存在相关性,而与密度是否均匀、病灶直径、有无纵隔脂肪线和是否侵犯心包、胸膜无关。因此,胸腺瘤螺旋CT影像特征与CKP、VEGF表达明显相关,为胸腺瘤的诊断提供了一种便捷的方法,对该病的临床诊断及治疗具有重要价值。 |
| 英文摘要: |
| To investigate the correlation between the CT features of thymoma and the expression of cytokeratin (CKP) and vascular endothelial growth factor (VEGF). Retrospectively analyzed the clinical datas of 83 patients with thymoma, who were treated in our hospital, summarized the imaging features of thymoma, and took the pathological section of the patient, then used immunohistochemical SP staining method to detect the expression of CKP and VEGF, analyzed the correlation between the CT image characteristics and the expression. The results showed that with increaseing of CT enhancement, the expression rate of positive VEGF became higher, while the positive CKP expression rate was independent with the CT enhancement. CKP expression in thymoma was correlated with whether the lesion had sharp or serrated appearance, uniform density, invasion of pericardium and pleura, and presence of mediastinal adipose line. It was not related to the appearance of lobes, lesion diameter and lung metastasis. The expression of VEGF in thymus tumor was correlated with whether the lesion had a sharp or serrated appearance, a lobulated appearance, and a metastasis in the lung.It was not related to the evenness of the density, the diameter of the lesion, the presence of mediastinal adipose line and the invasion of pericardium and pleura.Therefore, helical CT imaging features of thymoma are significantly correlated with CKP and VEGF expression,which provides a convenient method for the diagnosis of thymoma and is of great value to the clinical diagnosis and treatment of this disease. |
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