| 陈俊玲,杨芝春.Wilms肿瘤基因在生长发育及非肿瘤性疾病中作用研究.[J].中南医学科学杂志.,2018,(3):232-235, 246. |
| Wilms肿瘤基因在生长发育及非肿瘤性疾病中作用研究 |
| The research of Wilms' tumor gene in growth and non-neoplastic diseases |
| 投稿时间：2018-01-25 修订日期：2018-04-25 |
| DOI：10.15972/j.cnki.43-1509/r.2018.03.002 |
| 中文关键词: Wilms肿瘤基因 发育 疾病 生物学功能 |
| 英文关键词:WT1 development diseases biological function |
| 基金项目:国家自然科学基金面上项目(No.81673491)；湖南省自然科学基金(No.2015JJ3140). |
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| 中文摘要: |
| Wilms肿瘤基因(WT1)是与Wilms肿瘤密切相关的癌基因,具有锌指转录因子活性。近年来研究表明,WT1基因是维持组织器官生长发育的重要调控因子；当WT1基因表达异常时,除了作为抑癌或原癌基因参与多种肿瘤发生发展外,还与肥胖、糖尿病、高血压等非肿瘤性疾病关系密切。本文主要就WT1基因在生长发育及非肿瘤性疾病发生中的作用综述如下。 |
| 英文摘要: |
| The Wilms' tumor 1gene (WT1) encodes a zinc finger transcription factor and is associated with wilms' tumor. Recent studies have shown that WT1 is indispensable for normal development of many organs and tissues. Besides acting as a tumor suppressor or proto-oncogene, WT1 is also closely related to many non-neoplastic diseases such as obesity, diabetes and hypertension. This article mainly focuses on participation of WT1 gene in physiological development as well as in multiple diseases. |
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