| 严若梦,胡长平.环状RNA与心血管疾病.[J].中南医学科学杂志.,2018,(3):225-231. |
| 环状RNA与心血管疾病 |
| Circular RNA and cardiovascular diseases |
| 投稿时间：2018-03-26 修订日期：2018-04-17 |
| DOI：10.15972/j.cnki.43-1509/r.2018.03.001 |
| 中文关键词: 环状RNA 心血管疾病 心血管系统 |
| 英文关键词:circular RNAs cardiovascular diseases cardiovascular system |
| 基金项目:国家自然科学基金(91439105,81473209). |
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| 中文摘要: |
| 环状RNA是一类不具有5′末端帽子和3′末端poly(A)尾巴,由共价键形成闭环结构的RNA分子。大多数环状RNA广泛而稳定的存在于多种生物中,并且具有组织和细胞特异性。环状RNA能充当 microRNA 海绵,影响基因表达和调控,还能与蛋白质结合,作用于蛋白质翻译环节。越来越多研究表明,环状RNA在心血管疾病中起重要作用。本文总结了环状RNA的生物合成和功能方面的最新研究成果,对其在心肌梗死、心力衰竭、动脉粥样硬化、糖尿病心肌病等心血管疾病中的作用及机制进行综述,为诊断和治疗心血管疾病提供新思路。 |
| 英文摘要: |
| Circular RNA (circRNA) is a class of RNA molecules shaped by a covalently closed continuous loop, it lacks the typical 5′ cap and poly(A) tail. CircRNAs are abundent,stable,and specifically expressed in a cell type or tissue.Recent research indicates that the majority of circRNAs can serve as microRNA sponges, regulate gene expression andsplicing.Furthermore, circRNAs are able to bind with proteins mediating the translation of proteins.Emerging evidence supports that circRNAs play an important role in cardiovascular diseases.This study reviews the biosynthesis and function of circRNAs, and also discusses the circRNA classification, feature and their potential significance in myocardial infarction,heart failure,atherosclerosis,as well as diabetic cardiomyopathy,providing a new strategyfor future diagnosis and therapy in cardiovascular diseases. |
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