赵莲英,刘文利,程征涛,刘冬青,呼金田.他克莫司联合中药热敷及激光照射改善白癜风患者的疗效及机制.[J].中南医学科学杂志.,2018,(2):149-152.
他克莫司联合中药热敷及激光照射改善白癜风患者的疗效及机制
The mechanism of improving the therapeutic effect of tacrolimuscombined with Chinese traditional medicine hot compress and laserirradiation on patients with vitiligo
投稿时间:2017-01-13  修订日期:2018-02-27
DOI:10.15972/j.cnki.43-1509/r.2018.02.010
中文关键词:  白癜风  CD4+CD25+FOXP3+  调节性T细胞  他克莫司
英文关键词:vitiligo  CD4+CD25+FOXP3+  regulatory T cells  tacrolimus
基金项目:河北省科技计划项目(NO:15277733D) 
作者单位
赵莲英 河北工程大学附属医院激光美容科 河北 邯郸056002 
刘文利 河北工程大学附属医院激光美容科 河北 邯郸056002 
程征涛 河北省卫生监督局 
刘冬青 邯郸市第一医院检验科 
呼金田 河北工程大学附属医院激光美容科 河北 邯郸056002 
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中文摘要:
      观察在他克莫司软膏治疗的基础上配合中药热敷与308nm准分子激光照射对白癜风的治疗效果的影响,并探讨其机制。结果显示中药热敷与308nm准分子激光照射能改善他克莫司对白癜风的治疗效果,并且可提高患者血清CD4+,CD25+,Treg,CD4+CD25+FOXP3+Treg浓度。表明他克莫司联合中药热敷、308nm准分子激光照射治疗白癜风可显著提高临床疗效,其机制可能通过调控调节性T细胞CD4+CD25+FOXP3+改善机体免疫机能。
英文摘要:
      This study observed the effect of Chinese traditional medicine hot compress (CTMHC) and 308nm laser irradiation on the patients treated with tacrolimus ointment, and explored its mechanism. It showed that the CTMHC and laser irradiation can improve treatment effect, and significantly lower CD8+, increase the serum concentration of CD4+CD25+Treg and CD4+CD25+FOXP3+Treg. The results indicate that tacrolimus combined with CTMHC and laser irradiation can significantly improve the clinical efficacy in the treatment of vitiligo, and the mechanism improves the immune function by regulating CD4+CD25+FOXP3+ regulatory T cells.
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