| 付由户,张玉平,王雷,翦耀文,钟媛,让蔚清.鼻咽癌三维适形放射治疗疗效及安全性的Meta分析.[J].中南医学科学杂志.,2018,(1):6-12. |
| 鼻咽癌三维适形放射治疗疗效及安全性的Meta分析 |
| Meta-analysis of efficacy and safety of three-dimensionalconformalradiotherapy for treating nasopharyngeal carcinoma |
| 投稿时间：2017-09-03 修订日期：2017-12-08 |
| DOI：10.15972/j.cnki.43-1509/r.2018.01.002 |
| 中文关键词: 三维适形放射治疗 鼻咽癌 疗效 安全性 Meta分析 |
| 英文关键词:3D-CRT nasopharyngeal carcinoma efficacy safety Meta-analysis |
| 基金项目:国家自然科学基金面上项目资助(81673107)；湖南省教育厅科学研究重点项目资助(16A185)；“公共卫生与预防医学”湖南省重点学科经费资助；“疾病控制评价研究中心”衡阳市及南华大学重点实验室经费资助(NHSYS04). |
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| 中文摘要: |
| 鼻咽癌是头颈部肿瘤中常见的一种恶性肿瘤,治疗方法以放射治疗为主,其中包括三维适形放疗与常规放疗。本研究通过收集从建库起至2017年6月有关三维适形放疗与常规放疗治疗鼻咽癌患者的随机对照试验进行Meta分析。结果共纳入10篇随机对照研究,总样本量986例,实验组(三维适形放疗)481例,对照组(常规放疗)505例。与常规放疗相比,三维适形放疗能有效提高患者的近期生存率与局控率,且降低了放射性张口困难的发生风险。本研究通过增大样本量得出更可靠的结论,为鼻咽癌放疗临床实践提供依据。 |
| 英文摘要: |
| NPC(Nasopharyngeal carcinoma) is a common malignant tumor of head and neck cancer,and its treatment with radiation therapy includes three-dimensional conformal radiotherapy and conventional radiotherapy.This study is a Meta analysis through collecting published RCT(randomized controlled trials) articles on three-dimensional conformal radiotherapy and conventional radiotherapy for nasopha-ryngeal carcinoma patients from each database inception to June,2017.In result,10 RCT.The total sample size is 986 cases,with 481 cases in the experimental group (3D-CRT)and 505 cases in the control group (conventional therapy).Compared with conventional radiotherapy,three-dimensional conformal radiotherapy can improve the short-term survival rate and local control rate,and reduce the risk of radioactive mouth trouble of NPC patients.This research obtained more reliable conclusions by increasing the sample size,providing the basis for radiotherapy of nasopharyngeal carcinoma in clinical practice. |
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