| 齐峰,翟采文,张功学.肺癌组织中p63蛋白及CK5/6的表达及临床病理特点.[J].中南医学科学杂志.,2017,(6):572-575. |
| 肺癌组织中p63蛋白及CK5/6的表达及临床病理特点 |
| Expression and clinical significance of p63 and CK5/6 in lung cancer |
| 投稿时间：2017-03-20 修订日期：2017-10-23 |
| DOI：10.15972/j.cnki.43-1509/r.2017.06.009 |
| 中文关键词: 肺癌 p63蛋白 CK5/6蛋白 表达阳性率 病理参数 |
| 英文关键词:lung cancer p63 protein CK5 / 6 protein expression positive rate pathological parameters |
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| 中文摘要: |
| 目的 探讨肺癌组织中p63蛋白及CK5/6的表达及临床病理特点。方法应用免疫组化法检测100例肺癌患者肺癌组织中p63及CK5/6蛋白质的表达,并观察其临床病理特点。结果p63、CK5/6蛋白表达阳性率分别为56%、45%,阴性表达率分别为44%、55%；男性p63、CK5/6蛋白表达阳性率分别为60%、51.25%,显著高于女性的30%、15.00%；腺癌、鳞状细胞癌、腺鳞癌及小细胞肺癌其p63、CK5/6蛋白表达阳性率存在显著差异,且p63与CK5/6表达间存在正相关关系。结论肺癌患者的性别、病理类型均与p63及CK5/6的蛋白表达有关,这两种蛋白表达间存在正相关关系。 |
| 英文摘要: |
| Objective To detect the expression of p63 and CK5/6 in lung cancer and to evaluate their clinical significance.MethodsThe expressions of p63 and CK5/6 in 100 cases of lung cancer patients were detected by immunohistochemical method,and the clinicopathological features were observed.ResultsThe positive rate of p63 and CK5/6 protein expression in lung cancer was 56%,45%,negative rate was 44% and 55%；The positive rate of p63 and CK5/6 protein expression in male was 60%,51.25%,which was higher than 30 %,15% in female;There was a significant difference in the positive rate of p63 and CK5/6 protein expression in adenocarcinoma,squamous cell carcinoma,adenosquamous carcinoma and small cell lung cancer.There was a positive correlation between p63 protein expression and CK5/6 expression in lung cancer tissues.ConclusionGender and pathological types of lung cancer patients were related to the protein expression of p63 and CK5/6,and there was a positive correlation of protein expression between p63 and CK5/6. |
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