| 张丹.大剂量盐酸溴己新对ARDS患者脱机时间的影响.[J].中南医学科学杂志.,2017,(6):555-557. |
| 大剂量盐酸溴己新对ARDS患者脱机时间的影响 |
| Effect of high dose hydrochloride bromhexine on offline time of ARDS patients |
| 投稿时间：2017-05-25 修订日期：2017-09-20 |
| DOI：10.15972/j.cnki.43-1509/r.2017.06.005 |
| 中文关键词: 盐酸溴己新 急性呼吸窘迫综合征(ARDS) 机械通气 脱机时间 |
| 英文关键词:hydrochloride bromhexine acute respiratory distress syndrome (ARDS) mechanical ventilation offline time |
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| 中文摘要: |
| 目的 研究大剂量盐酸溴己新治疗急性呼吸窘迫综合征(ARDS)对患者脱机时间的影响。方法100例ARDS患者分为观察组(采用大剂量盐酸溴己新治疗)和对照组(采用常规剂量盐酸溴己新治疗)；比较两组治疗痰液性质、氧合指数、肺功能、脱机时间以及并发症等。结果疗程结束后,与对照组比较,观察组痰液性质较稀或稀薄质地明显改善(64% vs 84%),24 h痰量,氧合指数(OI)、动脉CO2分压(PaCO2)、气道峰压(Paw)及平台压(Pplat)、肺顺应性(C)测量水平也显著增高,PaCO2,气道阻力变化值(ΔR)和呼吸浅快指数均值显著降低,脱机时间明显短,并发症总发生率明显降低。结论大剂量盐酸溴己新能够有效保护ARDS患者肺功能,帮助患者提前脱机。 |
| 英文摘要: |
| Objective To study the effect of high dose hydrochloride bromhexine on offline time in patients with acute respiratory distress syndrome (ARDS).Methods100 patients with ARDS were divided into observation group(treated with high dose hydrochloride bromhexine)and control group(treated with routine dose hydrochloride bromhexine),and the sputum,oxygenation index,lung function,offline time and complications were compared.ResultsAfter treatment,compared to the control group,the rate of sputum changes into thin texture of the observation group was significantly higher (64% vs 84%),24 h sputum volume,OI,Paw,Pplat,C measurements level were significantly higher,PaCO2,ΔR level and shallow rapid breathing index were lower,offline time was apparently shorter,and the total complications incidence rate of the observation group was significantly lower.ConclusionHigh dose hydrochloride bromhexine can effectively protect the lung function of patients with ARDS and help patients to be offline early. |
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