| 黄馨谅,白跳,崔莹雪,邵亚婷.慢性阻塞性肺疾病患者和肽素、高迁移率族蛋白1水平变化及其临床意义.[J].中南医学科学杂志.,2017,(6):551-554. |
| 慢性阻塞性肺疾病患者和肽素、高迁移率族蛋白1水平变化及其临床意义 |
| Clinical significance of Copeptin and HMGB1 in patientswith chronic obstructive pulmonary disease |
| 投稿时间：2017-03-24 修订日期：2017-09-29 |
| DOI：10.15972/j.cnki.43-1509/r.2017.06.004 |
| 中文关键词: 慢性阻塞性肺疾病 和肽素 高迁移率族蛋白1 白介素-1β 肿瘤坏死因子-α |
| 英文关键词:chronic obstructive pulmonary disease copeptin HMGB1 IL-1β TNF-α |
| 基金项目: |
|
| 摘要点击次数: 907 |
| 全文下载次数: 634 |
| 中文摘要: |
| 目的 探讨慢性阻塞性肺疾病患者(COPD)中和肽素(Copeptin)、高迁移率族蛋白1(HMGB1)水平变化及其临床意义。方法72例COPD患者,按病情分为轻度组(n=15)、中度组(n=28)、重度组(n=29)。分析各组患者Copeptin、HMGB1水平变化。结果随着病情由轻到重,患者血清Copeptin、HMGB1、白介素(IL)-1β、肿瘤坏死因子(TNF)-α水平和肺组织HMGB1 mRNA及其蛋白水平依次均显著升高。重度组患者住院天数均长于轻度、中度组。急性加重期患者血清Copeptin水平与住院天数呈正相关。结论COPD 患者的严重程度和Copeptin及HMGB1表达水平呈正相关, Copeptin及HMGB1表达水平均可作为临床上评价COPD 的严重程度的生物学指标。 |
| 英文摘要: |
| Objective To evaluate the clinical significance of Copeptin and HMGB1 in patients with chronic obstructive pulmonary disease (COPD).Methods72 patients with COPD in our hospital were analyzed,and divided into mild group (n=15),moderate group (n= 28),severe group (n= 29) according to COPD comprehensive evaluation by the disease from mild to severe.The levels of Copeptin and HMGB1 and the clinical significance of them in patients with COPD were evaluated.ResultsThe levels of serum Copeptin,HMGB1,IL-1β,TNF-α,tissue HMGB1 mRNA and protein were elevated with degree of COPD.Hospitalization days in severe group were statistically significantly longer than those of mild,moderate groups.The Copeptin levels and hospitalization days among patients with acute exacerbation had positive correlation.ConclusionThe severity of COPD was positively related to the levels of Copeptin and HMGB1.Therefore,which can be used as a biological indicator to evaluate the severity of COPD in clinic. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |