| 彭科营.沙美特罗替卡松联合噻托溴铵治疗COPD并发重度支气管哮喘的临床效果观察.[J].中南医学科学杂志.,2017,(6):544-547. |
| 沙美特罗替卡松联合噻托溴铵治疗COPD并发重度支气管哮喘的临床效果观察 |
| Clinical observation of salmeterol/ticyclofen combined with tiotropium ontreatment of COPD complicated with severe bronchial asthma |
| 投稿时间：2017-03-24 修订日期：2017-07-23 |
| DOI：10.15972/j.cnki.43-1509/r.2017.06.002 |
| 中文关键词: 沙美特罗 替卡松 噻托溴铵 哮喘 慢性阻塞性肺病 |
| 英文关键词:salmeterol ticycallone tiotropium asthma COPD |
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| 中文摘要: |
| 目的 研究沙美特罗/替卡松联合噻托溴铵治疗慢性阻塞性肺病(COPD)并发重度支气管哮喘的临床效果。方法68例COPD并发重度支气管哮喘患者分别给予沙美特罗/替卡松联合复方异丙托溴铵进行治疗(对照组),沙美特罗/替卡松联合噻托溴铵进行治疗(观察组),两组治疗方案均以1年为一个疗程。结果与对照组比较,观察组患者治疗后的第一秒用力呼气量(FEV1)占预计值的百分比、FEV1、FEV1/用力肺活量(FVC)均明显增高,哮喘发作次数明显减少,且发作间隔时间明显长于对照组,生活质量评分明显的升高；两组不良反应的总发生率均为8.8%。结论沙美特罗/替卡松联合噻托溴铵治疗COPD并发重度支气管哮喘的临床效果显著,明显好于沙美特罗/替卡松联合复方异丙托溴铵进行治疗,值得临床推广应用。 |
| 英文摘要: |
| Objective To study the clinical effect of salmeterol/ticyclofen combined with tiotropium on treatment of COPD complicated with severe bronchial asthma.Methods68 patients with COPD and severe bronchial asthma were randomly divided into two groups.The control group received salmeterol/ticyclofen combined with ipratropium bromide,the treatment group was treated with salmeterol/ticyclofen and tiotropium bromide.The treatment period was one year.ResultsCompared to the control group,the FEV1 and FEV1/FVC of observation group was significantly higher;the clinical symptoms of the observation group was significantly lower,and the onset interval of the observation group was significantly longer than the control;the score of life quality of the observation group was significantly higher than control.The total incidence of adverse reactions were 8.8%.ConclusionThe effect of salmeterol/ticycloxacin with tiotropium on the treatment of COPD complicated with severe bronchial asthma was significant,which was better than the group of salmeterol/ticyclofen combined with ipratropium bromide,and it is worthy forclinical application. |
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