彭科营.沙美特罗替卡松联合噻托溴铵治疗COPD并发重度支气管哮喘的临床效果观察.[J].中南医学科学杂志.,2017,(6):544-547.
沙美特罗替卡松联合噻托溴铵治疗COPD并发重度支气管哮喘的临床效果观察
Clinical observation of salmeterol/ticyclofen combined with tiotropium ontreatment of COPD complicated with severe bronchial asthma
投稿时间:2017-03-24  修订日期:2017-07-23
DOI:10.15972/j.cnki.43-1509/r.2017.06.002
中文关键词:  沙美特罗  替卡松  噻托溴铵  哮喘  慢性阻塞性肺病
英文关键词:salmeterol  ticycallone  tiotropium  asthma  COPD
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作者单位
彭科营 广东医科大学附属深圳龙华中心医院呼吸内科,广东 深圳 518110 
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中文摘要:
      目的 研究沙美特罗/替卡松联合噻托溴铵治疗慢性阻塞性肺病(COPD)并发重度支气管哮喘的临床效果。方法68例COPD并发重度支气管哮喘患者分别给予沙美特罗/替卡松联合复方异丙托溴铵进行治疗(对照组),沙美特罗/替卡松联合噻托溴铵进行治疗(观察组),两组治疗方案均以1年为一个疗程。结果与对照组比较,观察组患者治疗后的第一秒用力呼气量(FEV1)占预计值的百分比、FEV1、FEV1/用力肺活量(FVC)均明显增高,哮喘发作次数明显减少,且发作间隔时间明显长于对照组,生活质量评分明显的升高;两组不良反应的总发生率均为8.8%。结论沙美特罗/替卡松联合噻托溴铵治疗COPD并发重度支气管哮喘的临床效果显著,明显好于沙美特罗/替卡松联合复方异丙托溴铵进行治疗,值得临床推广应用。
英文摘要:
      Objective To study the clinical effect of salmeterol/ticyclofen combined with tiotropium on treatment of COPD complicated with severe bronchial asthma.Methods68 patients with COPD and severe bronchial asthma were randomly divided into two groups.The control group received salmeterol/ticyclofen combined with ipratropium bromide,the treatment group was treated with salmeterol/ticyclofen and tiotropium bromide.The treatment period was one year.ResultsCompared to the control group,the FEV1 and FEV1/FVC of observation group was significantly higher;the clinical symptoms of the observation group was significantly lower,and the onset interval of the observation group was significantly longer than the control;the score of life quality of the observation group was significantly higher than control.The total incidence of adverse reactions were 8.8%.ConclusionThe effect of salmeterol/ticycloxacin with tiotropium on the treatment of COPD complicated with severe bronchial asthma was significant,which was better than the group of salmeterol/ticyclofen combined with ipratropium bromide,and it is worthy forclinical application.
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