| 柏琴琴,刘芸槾,王秋平,胡倩,邓仲良,陈丽丽.衡阳市女性生殖道无乳链球菌的带菌状况及分子特征.[J].中南医学科学杂志.,2017,(5):459-464. |
| 衡阳市女性生殖道无乳链球菌的带菌状况及分子特征 |
| Presence and molecular characterization of Streptococcus agalactiaein genital tract specimens of women in Hengyang |
| 投稿时间：2017-02-06 修订日期：2017-08-28 |
| DOI：10.15972/j.cnki.43-1509/r.2017.05.008 |
| 中文关键词: 无乳链球菌 女性生殖道 耐药 分子特征 |
| 英文关键词:S. agalactiae women genital tract antimicrobial susceptibility molecular characterization |
| 基金项目:南华大学博士启动基金项目(2013XQD21)；衡阳市科技局项目(2015KS11). |
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| 中文摘要: |
| 目的 了解衡阳市女性生殖道无乳链球菌的带菌状况及分离株的分子特征。方法收集衡阳市3家教学医院的女性生殖道分泌物棉签拭子样本,对其中的无乳链球菌进行分离、鉴定和药敏分析,并对分离株的耐药基因、血清型、菌毛岛类型进行分析。结果无乳链球菌的检出率为0.88%(3/339)。1株分离株保存失败,另外2株分离株HY66和HY9-2均对四环素和红霉素耐药,并携带ermB和tetO耐药基因。此外,HY9-2对克林霉素、左氧氟沙星、加替沙星耐药,还携带tetM和tetL耐药基因。2株分离株的血清型为Ⅲ型,同时携带PI-1和PI-2a菌毛岛。结论衡阳市女性生殖道无乳链球菌的带菌率低。分离株都对红霉素和四环素耐药,并出现了多重耐药菌株。为防治无乳链球菌的感染,应加强无乳链球菌的流行及耐药情况监测。 |
| 英文摘要: |
| Objective To investigate the prevalence rate and molecular characterization of Streptococcus agalactiae in genital tract swabs of women in Hengyang city.MethodsThe genital tract swabs of women which were collected from 3 teaching hospitals in Hengyang,were used to screen for S. agalactiae colonization. Then,isolates were detected for antimicrobial susceptibility,and their serotypes,pilus island types and genes encoding resistance were studied.ResultsAmong 339 genital tract swabs,3(0.88%) were positive for S. agalactiae. Except for one isolate that was failed for storage,the other two isolates HY66 and HY9-2 was both resistant to erythromycin and tetracycline,and carried the ermB gene with tetO gene. The isolate HY9-2 was also resistant to climdamycin,levofloxacin and gatifloxacin,and carried another two tetracycline resistance gene:tetM and tetL. The 2 isolates belong to serotype Ⅲ,their pilus island type consisted in the concomitant presence of PI-1 and PI-2a.ConclusionThe prevalence rate of S. agalactiae in genital tract swabs of women in Hengyang is low. The 2 isolate was resistant to erythromycin and tetracycline,and a multi-drug resistance isolates was obtained. The monitoring of prevalence of S. agalactiae and drug resistance should be strengthened for the prevention of S. agalactiae infection in Hengyang. |
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