| 尤建鹏,米玉茹,钟诚.阿托伐他汀钙联合依折麦布治疗冠心病的临床疗效和不良反应观察.[J].中南医学科学杂志.,2017,(5):442-445. |
| 阿托伐他汀钙联合依折麦布治疗冠心病的临床疗效和不良反应观察 |
| The clinical efficacy and adverse reactions of atorvastatin combined with ezetimibe in treatment of coronary heart disease |
| 投稿时间：2016-12-16 修订日期：2017-09-11 |
| DOI：10.15972/j.cnki.43-1509/r.2017.05.004 |
| 中文关键词: 阿托伐他汀 依折麦布 冠心病 临床疗效 不良反应 |
| 英文关键词:atorvastatin ezetimibe coronary heart disease clinical efficacy adverse reaction |
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| 中文摘要: |
| 目的 评价阿托伐他汀联用依折麦布治疗冠心病的临床疗效和不良反应。方法309例冠心病患者分为观察组、对照1组和对照2组,各103例。观察组采用阿托伐他汀联用依折麦布治疗,对照1组采用依折麦布治疗,对照2组采用阿托伐他汀治疗,比较三组患者治疗前后总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、超敏C-反应蛋白(hs-CRP)水平、左室射血分数(LVEE)、内皮舒张功能(FMD)、治疗有效率以及不良反应发生率。结果治疗后,三组患者TC、TG、LDL-C水平均低于治疗前,HDL-C高于治疗前,观察患者的TC、TG、LDL-C水平均显著低于对照组；与对照组相比,观察组患者hs-CRP水平较低,观察组患者LVEE及FMD均较高,治疗有效率高,不良反应发生率低。结论阿托伐他汀钙结合依折麦布治疗冠心病的疗效显著,降血脂效果好,不良反应少。 |
| 英文摘要: |
| Objective To investigate the clinical efficacy and adverse reactions of atorvastatin calcium combined with ezetimibe in patients with coronary heart disease.Methods309 coronary heart disease patients in our hospital were selected as the research object,which were randomly divided into three groups,each group got 103 cases.The observation group was treated with atorvastatin combined with ezetimibe,while the control group 1 with ezetimibe treatment,the control group 2 was treated with atorvastatin.Total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL-C),high density lipoprotein cholesterol (HDL-C),high sensitive C- reactive protein (hs-CRP) level,left ventricular ejection fraction (LVEE),flow-mediated dilatation (FMD),treatment efficiency and adverse reaction rate were compared among the three groups before and after treatment.ResultsAfter treatment,the levels of TC,TG and LDL-C in the three groups were lower than those before treatment,HDL-C was higher than that before treatment.The levels of TC,TG and LDL-C in the observation group were significantly lower than those in the control group.Compared to the control group,the level of hs-CRP in the observation group was lower,LVEE and FMD in the observation group were significantly higher,effective rate of the observation group was significantly higher,the incidence of adverse reactions in the observation group was significantly lower.ConclusionThe efficiency of atorvastatin combined with ezetimibe in the treatment of coronary heart disease was significant,with lower blood lipid,and less adverse reaction. |
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