| 张德龙,殷莉,姜芳,郭芳,郝伟华.盐酸曲美他嗪联合阿托伐他汀对不稳定型心绞痛患者PCI治疗围手术期临床效果研究.[J].中南医学科学杂志.,2017,(5):438-441. |
| 盐酸曲美他嗪联合阿托伐他汀对不稳定型心绞痛患者PCI治疗围手术期临床效果研究 |
| Clinical effect of trimetazidine hydrochloride and atorvastatin on percutaneous coronary intervention in patients with unstable angina pectoris in perioperative period |
| 投稿时间：2017-04-07 修订日期：2017-08-30 |
| DOI：10.15972/j.cnki.43-1509/r.2017.05.003 |
| 中文关键词: 曲美他嗪 阿托伐他汀 心绞痛 临床观察 血脂 |
| 英文关键词:Trimetazidine atorvastatin angina pectoris clinical observation lipid |
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| 中文摘要: |
| 目的 探讨盐酸曲美他嗪联合阿托伐他汀对于不稳定心绞痛患者经皮冠状动脉介入治疗围手术期的临床效果。方法将178例经皮冠状动脉介入治疗不稳定心绞痛患者均分为两组,每组89例,对照组采用阿托伐他汀进行治疗,观察组患者采用阿托伐他汀联合曲美他嗪进行治疗。比较两组患者治疗前后的体内炎症因子(INF,Hs-CRP,IL-40)变化,IL-40水平变化以及血脂(TC、TG、LDL-C、HDL-c)水平变化,并比较两组患者心脏不良事件的发生情况及临床总有效率。结果与治疗前比较,两组患者的TC、TG、LDL-C水平均明显降低,HDL-c水平均明显升高,且观察组变化更明显。治疗后,与对照组比较,观察组患者体内的干扰素(TNF)-α、INF-γ和Hs-CRP均明显降低,IL-40明显增高；总有效率分别是69.7%和86.5%,心脏不良事件发生率明显降低(P均＜0.05)。结论曲美他嗪联合阿托伐他汀在不稳定型心绞痛患者经皮冠状动脉介入治疗围手术期临床效果显著,且心脏不良事件发生率更低,可能与两药联合明显改善患者体内的炎症水平和血脂水平有关。 |
| 英文摘要: |
| Objective To study the clinical effect of trimetazidine hydrochloride and atorvastatin on percutaneous coronary intervention (PCI) in patients with unstable angina pectoris.MethodsA total of 178 patients with unstable angina pectoris treated with percutaneous coronary intervention were divided into two groups,the patients in the control group were treated with atorvastatin,the observation group were treated with atorvastatin and trimetazidine(n=89).The incidence of adverse,cardiac events,changes of inflammatory factors (TNF-α,INF,IL-40 and Hs-CRP) and lipid (TC,TG,LDL-C and HDL-c) level were compared in both groups.ResultsCompared to before treatment,the level of TC,TG,LDL-C and HDL-c of the two groups were significantly proved.After treatment,compared to control group,the level of TNF-α,INF-γ and Hs-CRP in the observation group was significantly lower,while the IL-40 was significantly higher than the control,the total effective rate was 69.7% and s86.5% respectively,and overall incidence of adverse events was significantly different (P<0.05).ConclusionThe clinical effect of Trimetazidine and atorvastatin in patients with unstable angina percutaneous coronary is significant,the level of inflammation and lipid was improved,the incidence of adverse cardiac events was lower,the total clinical effective rate is higher,it was worthy for application. |
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