| 程俊,雷张涛.HPV基因分型对ASCUS细胞临床应用的价值.[J].中南医学科学杂志.,2017,(4):388-390. |
| HPV基因分型对ASCUS细胞临床应用的价值 |
| Clinical value of human papillomavirus genotype in ASCUS |
| 投稿时间：2017-01-12 修订日期：2017-03-05 |
| DOI：10.15972/j.cnki.43-1509/r.2017.04.015 |
| 中文关键词: 非典型鳞状上皮细胞 人乳头瘤病毒 病理活检 高危型 |
| 英文关键词:atypical squamous cells of undetermined significance (ASCUS) human papillomavirus (HPV) pathologic biopsy high risk |
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| 中文摘要: |
| 目的 了解未明确意义的不典型鳞状上皮细胞(ASCUS)患者人乳头瘤病毒(HPV)亚型感染的分布情况,为临床ASCUS患者诊治提供相关理论依据。方法经宫颈细胞学检查确诊为ASCUS患者328例,流式细胞仪检测HPV型别,阴道镜下进行病理活检。结果ASCUS患者主要分布在30~50岁年龄段,其中HPV阳性263例,阳性率80.18%,HPV阳性患者宫颈病理结果为宫颈上皮内瘤变(CIN)-Ⅰ、CIN-Ⅱ、CIN-Ⅲ的检出率高于HPV阴性。此外,ASCUS患者中感染单-HPV高危型前四位和感染率分别是HPV 16(15.85%),52(10.67%),18(8.84%),58(7.93%),多重HPV高危型感染率为7.93%。结论对于细胞学检查筛查为ASCUS的患者,可联合HPV分型和阴道镜下活检,提高诊断的准确性。 |
| 英文摘要: |
| Objective To learn the prevalence of infection by different subtypes of human papillomavirus (HPV) patients diagnosed as atypical squamous cells of undetermined significance (ASCUS),and provide theory evidence of treatment and diagnosis for ASCUS patients.Methods328 patients were diagnosed as ASCUS by cytologic test,flow cytometry was used to detect HPV genotypes,and pathologic biopsy was examined under the colposcope.ResultsASCUS patients were mainly distributed at the age of 30 to 50,3 cases were positive HPV,the rate was 80.18%,moreover,the detection rate of positive HPV were much higher than the negative ones in cervical intraepithelial neoplasia (CIN).In addition,the top of HR-HPV genotypes and infection rates were HPV 16(15.85%),52(10.67%),18(8.84%),58(7.93%)respectively,the multiple HR-HPV infection rate was 7.93%.ConclusionFor ASCUS patients diagnosed with cytologic test should combine the result of HPV genotypes and colposcopy biopsy to promote clinical diagnostic accuracy. |
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