| 何煦芳,全会标,魏伟平,张华川,陈道雄,方团育,陈开宁.艾塞那肽联合二甲双胍治疗新诊断超重或肥胖2型糖尿病的疗效及后续观察.[J].中南医学科学杂志.,2017,(4):369-373. |
| 艾塞那肽联合二甲双胍治疗新诊断超重或肥胖2型糖尿病的疗效及后续观察 |
| Observation on combination of exenatide and metformin treating newly- diagnosed type 2 diabetic patients that are overweight or obese |
| 投稿时间：2016-12-29 修订日期：2017-05-30 |
| DOI：10.15972/j.cnki.43-1509/r.2017.04.010 |
| 中文关键词: 2型糖尿病 肥胖 艾塞那肽 二甲双胍 |
| 英文关键词:type 2 diabetes mellitus obesity Metformin |
| 基金项目:海南省重点科技计划项目资助ZDXM20120046. |
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| 中文摘要: |
| 目的 评估艾塞那肽联合二甲双胍治疗新诊断超重或肥胖2型糖尿病(T2DM)患者的疗效及安全性,以及停用艾塞那肽12周后患者各项指标的变化。方法 选取新诊断超重或肥胖T2DM患者50例为研究对象,检测治疗前及艾塞那肽联合二甲双胍治疗12周后患者体重、血糖、C肽、胰岛素、脂联素、C反应蛋白(CRP)、肿瘤坏死因子(TNF-α)及抵抗素以及其他血液生化指标,而后停用艾塞那肽12周,再重复检测上述指标。结果艾塞那肽联合二甲双胍治疗改善了患者胰岛素抵抗和分泌功能,有效降低患者血糖(P<0.01),安全性好,低血糖发生率低,同时可减轻患者体重(P<0.01),升高患者脂联素水平(P<0.05),降低CRP(P<0.05)、TNF-α(P<0.01)及抵抗素水平(P<0.05)。即使停用艾塞那肽12周,患者体重也没有明显反弹(P>0.05),除血糖较前稍升高外(P<0.01),其余指标无显著变化。结论对新诊断超重或肥胖T2DM患者,艾塞那肽联合二甲双胍是安全、有效、优化的治疗方案,并且对患者体重及胰岛素抵抗的改善可产生一定的后续效应。 |
| 英文摘要: |
| Objective Objective This study evaluates the efficacy and safety of combination of Exenatide and metformin in the treatment of newly-diagnosed type 2 diabetic patients with overweight or obesity,and the change of indicators in patients after 12 weeks of withdrawal of Exenatide.Methods50 overweight or obese patients were chosen to detect body weight,blood glucose,C-peptide,Insulin,adiponectin,C-reactive protein,Tumor Necrosis Factor-а,resistin and other biochemical markers in blood before and 12 weeks after treatment.Detection were also repeated after 12 weeks of Exenatide withdrawal.ResultsInsulin resistance and secreting function were well-improved with the treatment of Exenatide and metformin.Blood glucose was reduced effectively and safely with low incidence of hypoglycemia(P<0.01).at the same time,weight loss(P<0.01),increase of adiponectin(P<0.05),decrease of CRP(P<0.05),TNF-α(P<0.01)and resistin(P<0.05) were also displayed during observation.There was no obvious weight regain or changes in other indicators even after 12 weeks of Exenatide withdrawal except a slight rise in blood glucose(P<0.01).ConclusionThe combination of Exenatide and Metformin is a safe,effective and optimized treatment for type 2 diabetic patients that are either overweight or obese.It also demonstrates legacy effects on weight management and improvement of insulin resistance. |
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