| 龙治峰,欧含笑,莫中成,谢远杰.精原细胞分化及维甲酸在其中的作用与机制研究进展.[J].中南医学科学杂志.,2017,(1):7-11. |
| 精原细胞分化及维甲酸在其中的作用与机制研究进展 |
| Advances in mechanisms of spermatogonial differentiation andfunction of retinoic acid in this process |
| 投稿时间：2017-03-28 修订日期：2017-10-26 |
| DOI：10.15972/j.cnki.43-1509/r.2017.01.002 |
| 中文关键词: 精原细胞 分化 维甲酸 microRNA RNA结合蛋白 |
| 英文关键词:spermatogonia differentiation retinoic acid microRNA RNA binding protein |
| 基金项目:湖南省科技厅项目(2014SK3085)、湖南省卫生厅项目(B2013-037)及南华大学“蒸湘学者”唐向阳教授研究计划资助. |
|
| 摘要点击次数: 816 |
| 全文下载次数: 1611 |
| 中文摘要: |
| 目的 多种microRNAs及RNA结合蛋白参与调控精原细胞分化,维甲酸(retinoic acid,RA)在精原细胞分化过程发挥了重要作用,RA可通过调控microRNA及RNA结合蛋白影响Stra8、Sohlh1、Sohlh2及Kit等精原细胞分化决定因子的转录后加工、修饰,或直接激活mTOR信号通路促进精原细胞分化,但睾丸内调控精原细胞对RA反应的机制及RA作用于精原细胞后的下游分子机制尚未完全明确。 |
| 英文摘要: |
| Several microRNAs and RNA binding protein are involved in the differentiation of spermatogonia and retinoic acid (RA) has an important role in the process of spermatogonial differentiation.RA can affect the post-transcriptional modification and expression of its determinative factor such as Stra8,Sohlh1,Sohlh2 and Kit by regulating microRNAs and RNA binding protein,or directly activate mTOR signaling pathway and promote the differentiation of spermatogonia.However,mechanism of how to regulate spermatogonia response to RA and its downstream molecular pathway of RA acting on spermatogonia is not completely clear. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
| 关闭 |