| 陈劲松,刘运阳,曾高峰,刘访遥,黄冰,袁慧英.Toll样受体4信号通路分子与慢性心力衰竭严重程度和预后的关系分析.[J].中南医学科学杂志.,2016,(6):653-656, 714. |
| Toll样受体4信号通路分子与慢性心力衰竭严重程度和预后的关系分析 |
| The Relationship Between the Toll-like Receptor 4 Signaling Pathways and the Severity and Prognosis of Patients with Chronic Heart Failure |
| 投稿时间：2016-07-13 修订日期：2016-09-28 |
| DOI：10.15972/j.cnki.43-1509/r.2016.06.012 |
| 中文关键词: Toll样受体4 慢性心力衰竭 心功能 预后 |
| 英文关键词:Toll-like receptor 4 chronic heart failure cardiac function prognosis |
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| 中文摘要: |
| 目的 探讨Toll样受体4(TLR-4)信号通路分子变化与慢性心力衰竭(CHF)严重程度和预后的关系。方法选择本院收治的117例CHF患者(病例组)和同期109例健康对照者(对照组),采用流式细胞仪检测其外周血单核细胞中TLR-4、核转录因子kappa B(NF-κB)和髓样分化因子(MyD88)的表达情况,分析它们与CHF的心功能分级、浆膜腔积液、再次入院和全因死亡的关系。结果病例组的外周血单核细胞的TLR-4、NF-κB和MyD88水平均显著高于对照组(均P<0.05)；不同NYHA分级CHF患者的TLR-4(F=4.026,P=0.032)、NF-κB(F=5.152,P=0.025)和MyD88(F=7.323,P=0.019)水平具有显著差异；随访期间发生全因死亡患者的TLR-4(t=-2.149,P=0.033)和MyD88(t=-2.506,P=0.014)水平显著高于未死亡者；TLR-4作为预测发生全因死亡的灵敏度和特异度分别为83%和77%,而MyD88分别为77%和71%。结论TLR-4信号通路分子与CHF的心功能密切相关,TLR-4和MyD88是潜在的全因死亡预测分子。 |
| 英文摘要: |
| Objective To explore the relationship between the Toll-like receptor 4 (TLR-4) signaling pathways and the severity and prognosis of patients with chronic heart failure (CHF).MethodTotal 117 patients with CHF treated during June 2014 to May 2015 and 109 healthy controls were recruited;TLR-4,nuclear factor kappa B (NF-κB) and myeloid differentiation factor (MyD88) expression in peripheral blood mononuclear cells were examined by flow cytometry;the associations of these factors with CHF of NYHA,effusion,readmission,and all-cause mortality were analyzed.ResultsTLR-4,NF-κB and MyD88 in patients group were higher than control group (P<0.05);patients with different NYHA have significantly different TLR-4 (F=4.026,P=0.032),NF-κB (F=5.152,P=0.025) and MyD88 (F=7.323,P=0.019) levels;TLR-4 (t=-2.149,P=0.033) and MyD88 (t=-2.506,P=0.014) in patients who died due to the disease during follow-up were significantly higher than those who had not died;TLR-4 as a predictor of all-cause mortality had sensitivity and specificity of 83% and 77%,while MyD88 had 77% and 71%.ConclusionTLR4 signaling pathway molecules closely related to cardiac function of patients with CHF,TLR-4 and MyD88 may be potential all-cause mortality predictions in that disease. |
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