| 王环君,皮银珍,谭荣,李琳,刘罗坤,胡丽.新发2型糖尿病并代谢综合征患者颈动脉内膜中层厚度相关影响因素分析.[J].中南医学科学杂志.,2016,(5):527-530. |
| 新发2型糖尿病并代谢综合征患者颈动脉内膜中层厚度相关影响因素分析 |
| The Study of Correlation Factors of Carotid Intima-media Thickness in New Onset Type 2 diabetes Mellitus with Metabolic Syndrome |
| 投稿时间：2016-04-06 修订日期：2016-07-28 |
| DOI： |
| 中文关键词: 新发2型糖尿病 代谢综合征 颈动脉内膜中层厚度 |
| 英文关键词:new onset type 2 diabetes mellitus metabolic syndrome carotid intima-media thickness |
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| 中文摘要: |
| 目的 探讨新发2型糖尿病(T2DM)并代谢综合征(MS)患者颈动脉内膜中层厚度(IMT)的影响因素。方法选取在本院住院的新发T2DM患者80例,根据是否合并代谢综合征分为单纯T2DM组40例,T2DM合并MS组40例。比较单纯T2DM组和T2DM合并MS组两组患者的年龄、性别、血压(BP)、体重指数(BMI)；检测胰岛素抵抗指数(HOMA-IR)、血脂水平、糖化血红蛋白(HbA1c)、空腹及餐后2小时血糖(FPG、2hPG)、空腹及餐后胰岛素(FINS、PINS)等指标。同时测定IMT,分析各因素与IMT的相关关系。结果新发T2DM合并MS组患者的年龄、BMI、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、HOMA-IR、IMT均明显高于单纯T2DM组(P<0.05),HDL明显低于单纯T2DM组(P<0.05)。IMT与年龄、TG、LDL、HOMA-IR及合并MS成正相关(P<0.05),与HDL成负相关(P<0.05)。年龄、LDL、HOMA-IR及合并MS是IMT的独立影响因素。结论新发T2DM并MS较单纯T2DM患者更易发生糖尿病大血管病变,年龄、LDL、胰岛素抵抗及合并MS是新发T2DM患者颈动脉内膜病变的危险因素,应针对相关因素进行控制,防止糖尿病大血管病变的发生发展。 |
| 英文摘要: |
| Objective To investigate the correlation factors of carotid intia-media thickness(IMT) in new onset type 2 diabetes mellitus(T2DM) with metabolic syndrome(MS).MethodsA total of 80 new onset type 2 diabetes in our department were recruited in the study from July 2015 to February 2016,and then further divided into T2DM group (40 cases)and T2DM complicated with MS group (40 cases).We measured the age,sex,blood pressure(BP),body mass index(BMI),and the the insulin resistance was determined by homeostasis model assessment of insulin resistance(HOMA-IR),detected lipid level,high density lipoprotein-cholesterol(HDL-C) ,the hemoglobin A1c level(HbA1c),fasting plasma glucose(FPG),2-hour postprandial plasma glucose (2hPG) and fasting insulin concentration(FINS) and postprandial insulin(PINS).We evaluated all the patients’ IMT,and analysed the relationship between IMT and these factors.ResultsThe patients’age,BMI,TC,TG,LDL,HOMA-IR and IMT were higher in new onset T2DM patients complicated with MS group than in T2DM group(P<0.05),HDL was lower(P<0.05).There was positive correlation between IMT with age,TG,LDL,HOMA-IR and complicated with MS(P<0.05),and negative correlation with HDL(P<0.05).The IMT was related to age,LDL,insulin resistence and complicated with MS respectively.ConclusionThe patients with new onset T2DM suffering from MS were more susceptible to diabetic macrovascular disease compared to the ones just with T2DM.The age,LDL,insulin resistance and suffering from MS were risk factors for new onset type 2 diabetes with carotid atherosclerosis.We should try the best to control these factors,then to prevent the occurrence and development of diabetic macroangiopathy. |
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