| 彭传真,宋兆录,赵永利,李贵新,冷宁,李方超,李碧蓉.硫氧还蛋白还原酶活性在肺癌患者化疗前后的变化.[J].中南医学科学杂志.,2016,(4):425-427. |
| 硫氧还蛋白还原酶活性在肺癌患者化疗前后的变化 |
| The Alteratation of The Activity of Thioredoxin Reductase in Lung Cancer Patients Before and After Chemical Treatment |
| 投稿时间：2016-03-03 修订日期：2016-04-27 |
| DOI： |
| 中文关键词: 肺癌 硫氧还蛋白还原酶 化疗 活性 |
| 英文关键词:lung cancer thioredoxin reductase chemotherapy activity |
| 基金项目: |
| 作者 | 单位 | | 彭传真 | 青岛市胶州中心医院,山东 青岛,266300 | | 宋兆录 | 青岛市胶州中心医院,山东 青岛,266300 | | 赵永利 | 青岛市胶州中心医院,山东 青岛,266300 | | 李贵新 | 青岛市胶州中心医院,山东 青岛,266300 | | 冷宁 | 青岛市胶州中心医院,山东 青岛,266300 | | 李方超 | 青岛市胶州中心医院,山东 青岛,266300 | | 李碧蓉 | 邵阳医学高等专科学校生理教研室 |
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| 中文摘要: |
| 目的 探讨肺癌病人的血浆硫氧还蛋白还原酶(TR)活性及化疗前后的变化。方法收集2012年10月至2013年1月本院49例肺癌病人化疗前后的血浆和同期49例健康查体人员的血浆,进行硫氧还蛋白还原酶活性检测。结果49例肺癌病人化疗前血浆TR活性值为4.34±6.52 U/mL,化疗后为3.93±6.30 U/mL,健康查体人员为-5.61±7.39 U/mL,数据均采用LOG(X+4IQR)转换,并经t检验,结果显示,化疗前、后TR活性与健康查体组(对照组)相比较,P均<0.05。化疗前、后TR活性的变化,有统计学差异。结论肺癌病人的TR活性高；肺癌病人化疗前后血浆TR活性随疾病好转有降低。 |
| 英文摘要: |
| Objective To investigate the activity of thioredoxin reductase (TR) in lung cancer patients and the change before and after chemotherapy.Methods49 patients with lung cancer were enrolled in the study,49 healthy subjects served as control.The activity of TR in plasma was assayed.ResultsTR activity in the plasma of 49 patients with lung cancer before and aftrer chemotherapy is 4.34±6.52U/mL,and 3.93±6.30U/mL,respectively.While the healthy subjects is -5.61±7.39 U/mL.Use LOG(X+4IQR) transform and by group t test,result showed the activity of TR between before chemotherapy and healthy group (control group),and between after chemotherapy and healthy group were significant difference,(P<0.05).By paired t test,the change of the TR activity before and after chemotherapy was significant difference(P<0.05).ConclusionLung cancer patients have high TR activity,the plasma TR activity decreased with the improvement of the disease in the lung cancer patients before and after chemotherapy. |
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