| 陈莹,王德明,吴昆鹏,黄治家,言彩红.右美托咪定预处理对单肺通气后肺损伤的保护作用.[J].中南医学科学杂志.,2016,(3):323-327. |
| 右美托咪定预处理对单肺通气后肺损伤的保护作用 |
| Protection Effect of Pretreatment of Dexmedetomidine onLung Injury after One-Lung Ventilation |
| 投稿时间：2015-12-18 修订日期：2016-01-13 |
| DOI： |
| 中文关键词: 右美托咪定 单肺通气 肺损伤 |
| 英文关键词:Dexmedetomidine one-lung ventilation lung injury |
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| 中文摘要: |
| 目的 探讨右美托咪定预先给药对单肺通气后肺损伤的保护作用。方法选择择期行全麻单肺通气的食管癌病人56例,随机分为右美托咪定组和对照组各28例,分别于麻醉诱导后单肺通气前(T1)、单肺通气6Omin(T2)、120min(T3)、单肺通气结束前(T4)、出室前(T5)及术后24h(T6)时间点记录患者平均动脉压、心率、氧合指数、气道峰压和脑电双频指数值,并测定血清超氧化物歧化酶(SOD)、白介素(IL)-6、丙二醛(MDA)浓度。结果两组术中监测氧合指数在T2~T4时间点,右美托咪定组低于对照组(P<0.05)；除T1时间点外,T2~T6时间点血清IL-6、MDA浓度,右美托咪定组明显低于对照组(P<0.05),而SOD右美托咪定组明显高于对照组(P<0.05)；其余指标两组无差异。结论右美托咪定可显著减低单肺通气期间的炎症因子表达,改善术中的氧合指数,对单肺通气肺损伤有保护作用。 |
| 英文摘要: |
| Objective To investigate the effects of dexmedetomidine pretreatment on lung injury after one-lung ventilation(OLV).Methods56 cases of esophageal cancer patients undergoing elective single lung ventilation for general anesthesia,were randomly divided into two groups of Dexmedetomidine(Dex group)and control(NS group) with 28 cases in each group.Mean arterial pressure,heart rate,oxygenation index,airway peak pressure and BIS value were recorded in patients before OLV after anesthesia induction(T1),OLV after 60 min(T2),OLV after 120 min(T3),before the end of OLV(T4), before leaving the operating room(T5),and postoperative 24h(T6).The serum levels of SOD,IL-6 and MDA were measured.ResultsFor intraoperative monitoring oxygenation index in T2~T4 time points,Dex group is lower than the NS group (P<0.05)； IL-6 and MDA in Dex group significantly decreased at time point T2~T6 (P<0.05 ),SOD in Dex group significantly increased(P<0.05);the rest of the two groups have no difference.ConclusionDexmedetomidine can significantly decrease inflammatory factor during OLV and improve the technique of oxygenation index,protective lung injury after one lung ventilation. |
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