| 徐凯虹,周罗根,程宝金.匹多莫德辅助治疗婴幼儿支原体肺炎疗效观察及免疫功能变化.[J].中南医学科学杂志.,2016,(3):299-302. |
| 匹多莫德辅助治疗婴幼儿支原体肺炎疗效观察及免疫功能变化 |
| Effect of Pidotimod on Infantile Mycoplasma Pneumonia and Immunologic Function |
| 投稿时间：2015-11-29 修订日期：2016-04-06 |
| DOI： |
| 中文关键词: 婴幼儿支原体肺炎 匹多莫德 T淋巴细胞亚群 细胞因子 免疫球蛋白 |
| 英文关键词:infantile Mycoplasma pneumonia Pidotimod T cell subpopulations Cytokines Immune globulin |
| 基金项目: |
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| 中文摘要: |
| 目的 探讨匹多莫得辅助治疗对婴幼儿支原体肺炎患儿的T淋巴细胞亚群的百分比的影响及细胞因子和免疫球蛋白表达的变化。方法选取100例婴幼儿支原体肺炎患儿,随机分为观察组(n=50)和对照组(n=50)。对照组给予红霉素治疗,观察组采用红霉素联合匹多莫德治疗,比较两组患儿T淋巴细胞亚群、血清细胞因子、血清免疫球蛋白及临床疗效。结果与对照组比较,观察组患儿外周血中CD3+、CD4+和CD4+/CD8+细胞数显著升高,而CD8+细胞数则显著下降,两组间比较,其差异有显著性(P＜0.05)；观察组患儿血清中白细胞介素(IL)-12、IFN-γ的水平显著升高,而IL-6和IL-8的水平则明显下降(P＜0.05)；此外,观察组患儿血清IgM、IgG和IgA的水平较对照组增高(P＜0.05),并且观察组的临床疗效要优于对照组(92.0% vs 66.0%,P＜0.05)。结论匹多莫得佐治婴幼儿支原体肺炎,可显著改善患儿免疫功能,提高临床疗效,值得临床推广使用。 |
| 英文摘要: |
| Objective To evaluate the effect of pidotimod on T cell subpopulations,cytokines and immune globulin in infantile Mycoplasma pneumonia.Methods100 infantile Mycoplasma pneumonia were randomly divided into control group (n=50) and observation group (n=50).Pidotimod combined with erythromycin were used in observation group and erythromycin alone was used in control group.The T cell subpopulations,serum cytokines,serum immune globulin and clinical efficacy were compared between the two groups.ResultsAfter treatment,the CD3+,CD4+,CD4+/CD8+ of observation group significantly increased,and CD8+ were significantly reduced,statistically significant difference compared with control group(P＜0.05).The observation group serum IL-12,IFN-γ significantly increased,and IL-6,IL-8 were significantly reduced,statistically significant difference compared with control group(P＜0.05).The levels of IgM,IgG and IgA in observation group were significantly increased,statistically significant difference compared with control group(P＜0.05).The clinical efficacy of observation group was better than control group(92.0% vs 66.0%),showed significant differences between the two groups(P＜0.05).ConclusionUsing pidotimod treatment infantile Mycoplasma pneumonia can improve immune function,enhance curative effect,worth clinical promotion. |
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