| 马雅辉,王立.胰岛素类似物取代人胰岛素联合口服降糖药对糖尿病患者用药量和C肽-胰岛素释放的影响.[J].中南医学科学杂志.,2016,(3):296-298. |
| 胰岛素类似物取代人胰岛素联合口服降糖药对糖尿病患者用药量和C肽-胰岛素释放的影响 |
| The Dose of Insulin and the Release of Insulin and C-peptide in Patients with Diabetes after Treated with Insulin Analogues or Insulin Human Combined with Oral Medications |
| 投稿时间：2016-01-25 修订日期：2016-04-19 |
| DOI： |
| 中文关键词: 2型糖尿病 人胰岛素 胰岛素类似物 C肽-胰岛素 用药基础率 |
| 英文关键词: |
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| 中文摘要: |
| 目的 观察预混胰岛素类似物取代人胰岛素联合口服降糖药治疗2型糖尿病时的用药量及治疗后C肽-胰岛素的情况。方法将本院收治的2型糖尿病患者按自愿的方式分成胰岛素类似物组(60例)和人胰岛素组(50例)。所有患者均口服降糖药(二甲双胍)辅助治疗,胰岛素类似物组患者皮下注射诺和锐30降血糖,人胰岛素组患者皮下注射诺和灵30R降血糖。比较治疗期间两组患者的空腹血糖(FBG)、餐后2 h后血浆血糖(PBG)的含量、两组患者胰岛素总用量、治疗后C肽-胰岛素的情况。结果治疗期间,两组患者的空腹血糖含量和餐后2 h血糖含量较治疗前均显著下降,但组间差异无统计学意义(P＞0.05)；治疗期间实验组患者胰岛素总用量明显低于人胰岛素组患者胰岛素总用量(P＜0.05,P＜0.01)；胰岛素类似物组患者的胰岛素抵抗指数显著低于人胰岛素组患者(P＜0.05)。结论预混胰岛素类似物联合口服降糖药治疗2型糖尿病的临床效果优于应用人胰岛素联合口服降糖药的治疗效果,胰岛素类似物联合口服降糖药是一种值得推广的治疗2型糖尿病的方案。 |
| 英文摘要: |
| Objective To observe the dose of insulin and the release of insulin and C-peptide in patients who were with diabetes and treated with insulin analogues or insulin human combined with oral medications.Methods110 patients,who were received and treated because of diabetes at our hospital between May,2015 to December,2015,were divided into the experiment group(60 cases) and the control group(50 cases),according to the patients’ willing.All of the patients received oral hypoglycemic drugs(melbine),and patients in the experiment group were treated with insulin analogues(insulin Aspart 30),while patients in control group were treated with insulin(insulin Novolin 30R).Measure and compare the FBG,PBG,the supplemental dose of insulin,the release of insulin and C-peptide of patients in two groups.ResultsThe level of FBG and PBG of patients in two groups both went down after the treatment,but the difference between two groups was not statistically significant(P＞0.05).The dose of total insulin of patients in experiment group were statistically lower than those in control group(P＜0.05,P＜0.01).The HOMA-IR of patients in experiment group were lower than those in control group,and the difference is statistical(P＜0.05).ConclusionsInsulin analogues,instead of insulin human,combined with oral medications is a scheme deserved to be popularized. |
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