| 徐刚,洪丽,蒋穗斌.胶质瘤中Par6 蛋白的表达及其临床病理学意义.[J].中南医学科学杂志.,2016,(2):147-149. |
| 胶质瘤中Par6 蛋白的表达及其临床病理学意义 |
| The Expression and Clinical Pathological Significance of Par6 in Glioma |
| 投稿时间：2015-09-21 修订日期：2015-11-09 |
| DOI： |
| 中文关键词: 胶质瘤 Par6 侵袭 临床分期 |
| 英文关键词:Par6 Glioma invasion clinical stage |
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| 中文摘要: |
| 目的 检测Partitioning defective 6(Par6)蛋白在胶质瘤组织中的表达,分析其临床病理学意义,探讨Par6基因在胶质瘤发生发展中的作用。方法收集70例不同临床分期及不同分化程度胶质瘤组织及20例正常脑组织标本,应用免疫组化检测Par6蛋白的表达。结果与正常脑组织相比,胶质瘤组织中Par6蛋白表达水平显著降低(P＜0.05)。Par6蛋白在Ⅲ、Ⅳ级胶质瘤中的表达明显低于在Ⅰ、Ⅱ的胶质瘤。结论Par6蛋白在胶质瘤中低表达。其表达水平与胶质瘤的恶性程度密切相关。 |
| 英文摘要: |
| Objective To explore the role of Par6 in the development of glioma by analysis of the expression of Par6 in glioma tissue.Methods70 cases of human glioma tissue with different clinical period and differentiation histological type and 20 cases of normal brain tissue were selected.The protein of Par6 was detected by immunohistochemistry.ResultsCompared with normal brain tissue,the expression of Par6 protein in glioma tissue decreased significantly (P＜0.05).The expression level of Par6 was lower at stage Ⅲ~Ⅳ than that at Ⅰ~Ⅱ (Ⅰ~Ⅱ vs Ⅲ~Ⅳ;P=0.008).ConclusionThe expression of Par6 in glioma tissue decreased,and Par6 was involved in the development and progression of glioma,which was markedly correlated with clinical stage. |
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