| 朱中成,赵悦,王明,张明云,韩立杰,李兴德.小牛血去蛋白提取物对盆腔肿瘤急性放射性直肠炎患者的影响.[J].中南医学科学杂志.,2016,(1):78-81. |
| 小牛血去蛋白提取物对盆腔肿瘤急性放射性直肠炎患者的影响 |
| Effect of Deproteinized Extract of Calf Blood on Patients with Pelvic Tumor Complicated with Acute Radiation Proctitis |
| 投稿时间：2015-10-11 修订日期：2015-12-09 |
| DOI： |
| 中文关键词: 小牛血去蛋白提取物 盆腔肿瘤 急性放射性直肠炎 |
| 英文关键词:deproteinized extract of calf blood pelvic tumor acute radiation proctitis |
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| 中文摘要: |
| 目的 探讨小牛血去蛋白提取物对盆腔肿瘤急性放射性直肠炎患者的影响。方法随机选取76例盆腔恶性肿瘤需行放疗的患者,随机分为实验组和对照组,每组各38例。对实验组采用调强放疗配合小牛血去蛋白提取物静脉滴注,对照组采用常规治疗方法。观察对比两组患者放疗前、放疗5次后、放疗10次后、放疗15次后、放疗20次后、放疗25次后的C反应蛋白水平,以及治疗结束后发生急性放射性直肠炎患者的等级和人数。结果实验组患者在放射治疗前的C反应蛋白水平和对照组相近,但是放疗5次后、放疗10次后、放疗15次后、放疗20次后、放疗25次后实验组C反应蛋白水平较对照组明显降低(P<0.05)；实验组发生0级急性放射性直肠炎的人数为10例,对照组2例,二者差异显著(P=0.001)；实验组发生Ⅱ级急性放射性直肠炎为1例,对照组为9例,差异具有统计学意义(P=0.018)；实验组发生Ⅰ级和Ⅲ级急性放射性直肠炎的人数分别为27例和0例,对照组为23例和4例,两者差异不具有统计学意义(P>0.05)。实验组发生急性放射性直肠炎的平均时间较对照组明显延长,平均放射剂量也较对照组显著增加(P<0.05)。结论采用小牛血去蛋白提取物配合调强放疗对盆腔恶性肿瘤放疗患者并发急性放射性直肠炎防治效果显著,值得在临床中大力推广。 |
| 英文摘要: |
| Objective To explore and study the effect of deproteinized extract of calf blood on patients with pelvic tumor complicated with acute radiation proctitis.Methods76 cases of patients with pelvic tumor who needed radiotherapy in our hospital were randomly selected and randomly divided into experimental group and control group,with 38 cases in each group.The experimental group were treated with intensity modulated radiotherapy combined with deproteinized extract of calf blood for intravenous drips.The control group were treated with routine method.The C-reactive protein levels of two groups of patients before radiotherapy,after 5 times,10 times,15 times,20 times,and 25 times of radiotherapy were observed,as well as the level and the number of patients who occurred acute radiation proctitis.ResultsThe level of C-reactive protein of the patients in the experimental group was simillar with that in the control group before radiotherapy,but after 5 times,10 times,15 times,20 times,25 times of radiotherapy the levels in the experimental group were significantly lower than those in the control group (P<0.05).The number of experimental group who had grade 0 for acute radiation proctitis was 10 cases,2 cases in the control group,with significant difference between the two groups (P=0.001),and the number of patients in the experimental group who had grade Ⅱ for acute radiation proctitis were 1 case,9 cases in the control group,so the difference was statistically significant (P=0.018),and the number of patients in the experimental group who had I grade and Ⅲ grade for acute radiation proctitis were 27 cases and 0 case,23 cases and 4 cases in the control group,between which the differences were not statistical significance (P>0.05).In addition,the average time of patients in the experimental group who had acute radiation proctitis significantly was longer than that in the control group,and the average radiation dose also increased significantly compared with that in the control group (P<0.05).ConclusionThe use of deproteinized extract of calf blood combined with intensity modulated radiotherapy is effective on pelvic tumor complicated with acute radiation proctitis,which is worthy of promotion in clinical. |
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