| 冷玉萍.cTnI联合NT-proBNP对急性心肌梗死的早期诊断价值.[J].中南医学科学杂志.,2016,(1):51-53, 63. |
| cTnI联合NT-proBNP对急性心肌梗死的早期诊断价值 |
| Clinical Value of Combined Detection of Cardiac Troponin I and N-terminal Pro-brain Natriuretic Peptide in Early Diagnosis of Acute Myocardial Infarction |
| 投稿时间：2015-12-03 修订日期：2016-01-13 |
| DOI： |
| 中文关键词: 肌钙蛋白Ⅰ 氨基末端脑钠肽前体 心肌梗死 急性 早期诊断 |
| 英文关键词:cardiac troponin I N-terminal pro-brain natriuretic peptide acute myocardial infraction early diagnosis |
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| 中文摘要: |
| 目的 探讨心肌钙蛋白I(cTnI)联合氨基末端脑钠肽前体(NT-proBNP)对急性心肌梗死早期诊断的临床应用价值。方法对2013年10月至2015年10月期间在本院心内科住院的71例首发急性心肌梗死患者(AMI组)病例为分析对象,另外选择同一时期的67例健康体检者作为健康对照组。分析两组全血cTnI和NT-proBNP水平。结果AMI患者的全血cTnI和NT-proBNP水平均显著高于对照组健康体检者(P<0.001),AMI患者cTnI和NT-proBNP都阳性的检出率明显高于cTnI或NT-proBNP的单个阳性率,且cTnI诊断AMI的敏感度和特异度分别为77.46%和85.07%,NT-proBNP诊断AMI的敏感度和特异度分别为80.28%和83.58%,cTnI和NT-proBNP两者诊断AMI的敏感度和特异度分别为88.73%和94.03%(χ2=54.111、56.249、94.524；均有P<0.001)。结论cTnI联合NT-proBNP监测能在AMI发病早期快速、准确地判断患者病情并及时作出诊断,有助于患者的早期、及时治疗,以降低AMI致死致残率。 |
| 英文摘要: |
| Objective To explore the clinical value of combined detection of cardiac troponin I (cTnI) and N-terminal pro-brain natriuretic peptide (NT-proBNP NT-proBNP) in early diagnosis of acute myocardial infarction.Methods71 patients with acute myocardial infarction delivered in our hospital served as the treatment group,and 67 healthy subjects served as the control.The blood plasma cTnI and NT-proBNP was detected.ResultThe cTnI and NT-proBNP of patients in treatment group were significantly higher than that of patients in control (all P<0.001).The AMI positive detection rate of combined detection of cardiac cTnI and NT-proBNP was significantly higher than that of detecting cTnI or NT-proBNP alone.The sensitivity and specificity of combined detection of cardiac cTnI and NT-proBNP was significantly higher than that of detecting cTnI or NT-proBNP alone (all P<0.001).ConclusionCombined detection of cardiac cTnI and NT-proBNP can monitor the progress of the disease timely and accurately,which can increase the sensitivity and specificity of the early diagnosis of acute myocardial infarction,decrease the mortality and disability of AMI and improve patients' prognosis and life quality. |
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