| 周志刚，胡啸玲，李丽丁，陈雪艳，严 欣，刘 伶，涂 剑.甲泼尼龙联合乌司他丁在PCNL并发脓毒血症中的应用.[J].中南医学科学杂志.,2015,43(6):624-626. |
| 甲泼尼龙联合乌司他丁在PCNL并发脓毒血症中的应用 |
| Application of Methylprednisolone Combined with Ulinastatin in Patients with Sepsis During PCNL |
| 投稿时间：2015-08-10 |
| DOI： |
| 中文关键词: 甲泼尼龙 乌司他丁 脓毒血症 经皮肾镜碎石术 |
| 英文关键词:Methylprednisolone Ulinastatin sepsis percutaneous nephrolithotomy （PCNL） |
| 基金项目:湖南省自然科学基金资助项目（2015JJ3101）；湖南省卫生厅科研基金资助项目（B2007101，B2007109）. |
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| 中文摘要: |
| 目的 探讨甲泼尼龙联合乌司他丁在经皮肾镜碎石术（PCNL）并发脓毒血症的临床应用效果。方法 选取39例PCNL并发脓毒血症患者作为研究对象，随机分为19例对照组和20例实验组，其中对照组采用常规治疗，实验组在常规治疗的基础上加用甲泼尼龙联合乌司他丁治疗。观察两组治疗好转率、急性生理和慢性健康状况评估（APACHE Ⅱ）测定情况及治疗前后血清肿瘤坏死因子（TNF-α）、C-反应蛋白（CRP）水平。结果 实验组治疗效果与APACHEⅡ评分明显优于对照组，TNF-α、CRP恢复更快，差异均有统计学意义（P<0.05）。结论 甲泼尼龙联合乌司他丁治疗PCNL并发脓毒血症，可显著提高治疗效果。 |
| 英文摘要: |
| Objective To explore the clinical effect of Methylprednisolone combined with Ulinastatin in PCNL complicated with sepsis. Methods 39 cases of patients in PCNL complicated with sepsis were randomly divided into two groups,the experimental group （20 cases） and the control group （19 cases）.The patients from the control group were given the conventional treatment,including anti-infective,nutritional support and symptomatic treatment while the patients from the experimental group were given the conventional treatment plus Methylprednisolone combined with Ulinastatin.Then,the effect of treatment,score of acute physiology and chronic health evaluation （APACHEⅡ） and level of TNF-α and CRP were observed. |
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