| 黄 晔.上消化道疾病患者幽门螺旋杆菌感染的调查分析.[J].中南医学科学杂志.,2015,43(5):542-545. |
| 上消化道疾病患者幽门螺旋杆菌感染的调查分析 |
| The Investigation and Analysis on the Helicobacter Pylori Infection Status of the Patients with Upper Gastrointestinal Tract Diseases |
| 投稿时间：2015-05-11 |
| DOI： |
| 中文关键词: 幽门螺旋杆菌 上消化道疾病 健康体检者 感染 阳性率 |
| 英文关键词:Helicobacter pylori upper gastrointestinal tract diseases healthy examinator infection positive rate |
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| 中文摘要: |
| 目的 调查分析上消化道疾病患者和健康体检者幽门螺旋杆菌感染的状况。 方法 随机选择经胃镜检查临床上确诊为上消化道疾病患者594例为实验组，同时随机选取体检自然人群，根据病史、无明显消化道症状及体检报告未见任何异常则确认为健康体检者共590例并作为对照对象，均采用14C-尿素呼气试验检测幽门螺旋杆菌。 结果 上消化道疾病患者幽门螺旋杆菌阳性总检出率为70.71%（420/594例），其中慢性胃炎、消化性溃疡、胃癌和反流性食管炎患者的阳性率分别为77.77%、84.37%、76.04%和28.70%，以消化性溃疡患者的幽门螺旋杆菌检出率最高（84.37%），反流性食管炎患者幽门螺旋杆菌检出率最低（28.70%）。不同的上消化道疾病患者组间幽门螺旋杆菌阳性检出率比较，差异有显著性（P＜0.001）；健康体检者幽门螺杆菌的阳性总检出率为54.92%（324/590例），与上消化道疾病患者比较，差异有显著性（P＜0.001）。 结论 幽门螺旋杆菌感染与慢性胃炎、消化性溃疡和胃癌的关系非常密切，而对反流性食管炎的发病有一定的保护作用；无明显消化道症状的健康体检者也有较高比例的幽门螺旋杆菌感染率。 |
| 英文摘要: |
| Objective To investigate and analyze the Helicobacter pylori infection status of patients with upper gastrointestinal tract diseases and healthy examinator. Methods We randomly selected 594 cases outpatients of our hospital from May 2013 to December 2014 who was clinically diagnosed as upper gastrointestinal tract diseases by gastroscope.At the same time we randomly selected 590 cases heathy examinators from the physical examination center as the control group.These patients were used by the method of 14C-urea breath test to detect the Helicobacter pylori. Results The total positive detection rate of Helicobacter pylori from the patients who were diagnosed with upper gastrointestinal tract diseases was 70.71% （420/594 cases）.Among them,the positive detection rates of the patients with chronic gastritis,peptic ulcer,gastric cancer and reflux esophagitis were respectively 77.77%,84.37%,76.04% and 28.70%.From the above data,we can see that patients with peptic ulcer had the highest detection rate（84.37%）,while patients with reflux esophagitis had the lowest （28.70%）.There were significant differences （P<0.001）between different kinds of upper gastrointestinal tract diseasesthe positive detection rate of the healthy examinators was only 54.92% （324/590 cases）which also had a significant difference （P<0.001），compared with the patients who had upper gastrointestinal tract diseases. Conclusions The infection of Helicobacter pylori is closely associated with the diseases of chronic gastritis,peptic ulcer,gastric cancer and possibly has protection effect in some extent to pathogenesis of reflux esophagitisHealth examinators with no obvious gastrointestinal tract symptoms can also have a higher proportion of Helicobacter pylor infection. |
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