| 李增波，冯 伟，欧阳熠烨.西地那非联合常频机械通气治疗新生儿.[J].中南医学科学杂志.,2015,43(4):418-419. |
| 西地那非联合常频机械通气治疗新生儿 |
| Effect of Sildenafil Combined with Conventional Ventilation Treatment of Persistent Pulm Onary Hypertension of the Newborn |
| 投稿时间：2014-12-15 |
| DOI： |
| 中文关键词: 西地那非 常频机械通气 新生儿 持续性肺动脉高压 |
| 英文关键词:Sildenafil conventional ventilation treatment the newborn PPHN |
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| 中文摘要: |
| 目的 探讨西地那非联合常频机械通气治疗新生儿持续性肺动脉高压（PPHN）的临床疗效与安全性。 方法 回顾性收集38例PPHN患儿的临床资料，并对其进行分析。其中应用西地那非联合常频机械通气治疗的22例为治疗组，常频机械通气治疗的16例为对照组，比较氧和指数（OI）、经皮血氧饱和度（SPO2）、氧分压（PaO2）、呼吸机使用时间及住院时间。 结果 治疗组和对照组OI、SPO2、PaO2、上机时间及住院时间差异比较有统计学意义（P＜0.05）。所有西地那非治疗的患儿在治疗过程中均未见明显不良反应。 结论 西地那非联合常频机械通气治疗PPHN的疗效确切，且未见明显的不良反应。 |
| 英文摘要: |
| Objective Study of sildenafil combined with conventional mechanical ventilation in treatment of neonatal clinical efficacy and safety of persistent pulm onary hypertension（PPHN）. Methods 38 cases of children with PPHN,were retrospectively analysed.Sildenafil combined with conventional mechanical ventilation was applied in the treatment of 22 cases of treatment group,conventional mechanical ventilation was used in the treatment of 16 cases in the control group,and the oxygen index（OI）,transcutaneous oxygen saturation（SPO2）,oxygen partial pressure（PaO2）,the duration of mechanical ventilation and hospitalization time were compared. Results The OI,SPO2,PaO2，operation time and hospitalization time difference between the treatment group and the control group was statistically significant （P＜0.05）.No side effect happened in all patients treated with sildenafil. Conclusion Sildenafil combined with conventional ventilation treatment is an efective and safe method to PPHN,and no side effect happened. |
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