| 刘美媛，王添柱，谭小军，胡晓晔，邹青峰.胃肠胰神经内分泌肿瘤临床病理特征及预后分析.[J].中南医学科学杂志.,2015,43(3):281-283. |
| 胃肠胰神经内分泌肿瘤临床病理特征及预后分析 |
| Clinic and Pathological Characteristics and Prognosis Analysis of Gastroenteropancreatic Neuroendocrine Neoplasma |
| 投稿时间：2015-02-11 |
| DOI： |
| 中文关键词: 胃肠胰神经内分泌肿瘤 临床特征 病理特征 预后 |
| 英文关键词:gastroenteropancreatic neuroendocrine neoplasma clinic characteristics pathological characteristics prognosis |
| 基金项目: |
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| 中文摘要: |
| 目的 分析胃肠胰神经内分泌肿瘤的临床及病理特点。 方法 收集本院病理诊断为胃肠胰神经内分泌肿瘤的病例15例，按照2010年第4版《WHO消化系统肿瘤分类》标准进行病理复核，回顾分析其临床资料，总结其临床及病理特点。 结果 15例胃肠胰神经内分泌肿瘤中，中位发病年龄为56岁。发病部位多见于食管，其次为胰腺，CgA阳性率为73%，Syn阳性率为87%，分期为IV期及病理分级为3级的患者预后差。 结论 胃肠胰神经内分泌肿瘤具有很高的异质性，临床分期及分级是主要的预后因素，早期诊断及治疗可改善患者预后。 |
| 英文摘要: |
| Objective To analyse the clinic and pathological features of gastroenteropancreatic neuroendocrine neoplasma （GEP-NEN）. Methods Medical records of 15 cases of GEP-NENs were collected in the Cancer Center of Guangzhou Medical University from 2000 to 2014，all the pathological specimens were reviewed according to WHO 2010 classfication of tumors of the digestive system.The data were analyzed retrospectively,and the clinical and pathological characteristics were summarized. Results Among the 15 patients,the median age at diagnosis was 56 years.More common sites of occurrence were esophagus and pancreas,CgA positive rate was 73%,the Syn positive rate was 87%.Patients with stage IV disease or whose pathology classification were G3 had a poor prognosis. Conclusion GEP-NEN has the very high heterogeneity，clinical staging and grading are the major prognostic factors.To achieve early diagnosis and treatment,clinical multidisciplinary cooperation is needed.Early diagnosis and treatment can improve prognosis of patients. |
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